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Biomedical Glasses

Editor-in-Chief: Boccaccini, Aldo R.

CiteScore 2018: 2.05

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Acellular Bioactivity of Sol-Gel Derived Borate Glass-Polycaprolactone Electrospun Scaffolds

William C. Lepry
  • Corresponding author
  • Department of Mining and Materials Engineering, McGill University, Montreal, QC, Canada
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  • De Gruyter OnlineGoogle Scholar
/ Sophia Smith
  • Corresponding author
  • Department of Mining and Materials Engineering, McGill University, Montreal, QC, Canada
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  • De Gruyter OnlineGoogle Scholar
/ Liliana Liverani
  • Corresponding author
  • Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Erlangen, Germany
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/ Aldo R. Boccaccini
  • Corresponding author
  • Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Erlangen, Germany
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/ Showan N. Nazhat
  • Corresponding author
  • Department of Mining and Materials Engineering, McGill University, Montreal, QC, Canada
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Published Online: 2016-12-14 | DOI: https://doi.org/10.1515/bglass-2016-0011


Recently, sol-gel derived borate glasses (BGs) have shown unprecedented conversion rates to bone-like mineral (hydroxycarbonated apatite). In an effort to explore their potential applications in bone tissue engineering, this study reports on the fabrication and characterization of BG particle incorporated electrospun "- polycaprolactone (PCL) fibrous composites. The electrospinning technique successfully incorporated PCL fibres with BG particles at 2.5 and 5 w/v%, with the higher BG loading creating a three-dimensional cotton-wool like morphology. Dynamic vapour sorption showed greater extents of mass change with BG content attributable to water sorption, and indicating greater reactivity in the composite systems. In vitro bioactivity was investigated in simulated body fluid for up to 7 days. Scanning electron microscopy, Fourier-transform infrared spectroscopy and xray diffraction indicated apatite formation in the 5 w/v% incorporated composite scaffold, which initiated as early as day 3. In summary, sol-gel derived BGs incorporatedfibrous electrospun PCL composites indicate rapid reactivity and bioactivity with potential applications in mineralized tissue engineering.

Keywords: Electrospinning; Borate Glass; Bioactivity; PCL; Scaffolds; Mineralization


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About the article

Received: 2016-08-23

Accepted: 2016-10-31

Published Online: 2016-12-14

Citation Information: Biomedical glasses, Volume 2, Issue 1, ISSN (Online) 2299-3932, DOI: https://doi.org/10.1515/bglass-2016-0011.

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© 2016 W. C. Lepry et al.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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