Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biomedical Glasses

Editor-in-Chief: Boccaccini, Aldo R.


CiteScore 2018: 2.05

SCImago Journal Rank (SJR) 2018: 0.424
Source Normalized Impact per Paper (SNIP) 2018: 0.562

Open Access
Online
ISSN
2299-3932
See all formats and pricing
More options …

Finite Element Modeling of the Flexural Mechanical Response of Polymer-Coated Bioactive Glass Scaffolds Composed of Thermally-Bonded Unidirectional Fibers

Wei Xiao
  • Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409-0340, United States of America
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mohsen Asle Zaeem
  • Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409-0340, United States of America
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Delbert E. Day
  • Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409-0340, United States of America
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mohamed N. Rahaman
  • Corresponding author
  • Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409-0340, United States of America
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-11-30 | DOI: https://doi.org/10.1515/bglass-2017-0008

Abstract

Bioactive glasses have attractive characteristics as a scaffold material for healing bone defects but their brittle mechanical response, particularly in bending, is a concern. Recent studies have shown that coating the external surface of strong porous bioactive glass (13-93) scaffolds with an adherent biodegradable polymer layer can significantly improve their load-bearing capacity andwork of fracture, resulting in a non-brittle mechanical response. In the present study, finite element modeling (FEM) was used to analyze the mechanical response in four-point bending of composites composed of a porous glass scaffold and an adherent polymer surface layer. The glass scaffold with a cylindrical geometry (diameter = 4.2 mm; porosity = 20%) was composed of randomly arranged unidirectional fibers (diameter 200-700 μm) thatwere bonded at their contact points. The thickness of the polymer layer was 500 μm. By analyzing the stresses in the individual glass fibers, the simulations can account for the main trends in the observed mechanical response of practical composites with a similar architecture composed of a bioactive glass (13-93) scaffold and an adherent polylactic acid surface layer. These FEM simulations could play a useful role in designing bioactive glass composites with improved mechanical properties.

Keywords: Finite element modeling; bioactive glass composites; mechanical behavior

References

  • [1] Hench L. L. The story of Bioglassr. JMater SciMater Med 2006; 17: 967-978.Google Scholar

  • [2] Gerhardt L-C., Boccaccini A. R. Bioactive glass and glassceramic scaffolds for bone tissue engineering. Materials 2010; 3: 3867-3910Google Scholar

  • [3] Rahaman M. N., Day D. E., Bal B. S., Fu Q., Jung S. B., Bonewald L. F., Tomsia A. P. Bioactive glass in tissue engineering. Acta Biomater 2011; 7, 2355-2373.Web of ScienceCrossrefGoogle Scholar

  • [4] Jones J. R. Review of bioactive glass - from Hench to hybrids. Acta Biomater 2012; 9: 4457-4486.Google Scholar

  • [5] Fu Q., Saiz E., Rahaman M. N., Tomsia A.P. Bioactive glass scaffoldsfor bone tissue engineering: state of the art and future perspectives. Mater Sci Eng C 2011; 31: 1245-1256.CrossrefGoogle Scholar

  • [6] Fu Q., Saiz E., Rahaman M. N., Tomsia A. P. Toward strong and tough glass and ceramic scaffolds for bone repair. Adv Funct Mater 2013; 23: 5461-5476.CrossrefWeb of ScienceGoogle Scholar

  • [7] Peroglio M., Gremillard L., Chevalier J., Chazeau L., Gauthier C., Hamaide T. Toughening of bio-ceramics scaffolds by polymer coating. JEur Ceram Soc 2007; 27: 2679-2685.Web of ScienceGoogle Scholar

  • [8] Martinez-Vazquez F. J., Perera F. H., van der Meulen I., Heise A., Pajares A., Miranda P. Impregnation of β-tricalcium phosphate robocast scaffolds by in-situ polymerization. J Biomed Mater Res A 2013;101: 3086-3096.Google Scholar

  • [9] Martinez-Vazquez F. J., Miranda P., Guiberteau F., Pajares A. Reinforcing bioceramic scaffolds with in-situ synthesized β-polycaprolactone coatings. J Biomed Mater Res A 2013; 101:3551-3559.Google Scholar

  • [10] Martinez-Vazquez F. J., Pajares A., Guiberteau F., Miranda P.Effect of polymer infiltration on the flexural behavior of β- tricalcium phosphate robocast scaffolds. Materials 2014; 7: 4001-4018.Google Scholar

  • [11] Chen Q. Z., Boccaccini A. R. Poly(D,L-lactic acid) coated 45S5Bioglassr-based scaffolds: processing and characterization. J Biomed Mater Res A 2006; 77: 445-457.Google Scholar

  • [12] Yunos D. M., Bretcanu O., Boccaccini A. R. Polymerbioceramiccomposites for tissue engineering scaffolds. J Mater Sci 2008; 43:4433-4442.CrossrefGoogle Scholar

  • [13] Philippart A., Boccaccini A. R., Fleck C., Schubert D. W., Roether J. A. Toughening and functionalization of bioactive ceramic and glass bone scaffolds by biopolymer coatings and infiltration: a review of the last 5 years. Expert Rev Med Devices 2015; 12: 93-111.Google Scholar

  • [14] Xiao W., Asle Zaeem M., Li G., Bal B. S., Rahaman M. N. Toughand strong porous bioactive glass-PLA composites for structural bone repair. J. Mater Sci 2017; 52: 9039-9054.CrossrefGoogle Scholar

  • [15] Day D. E., Mohammadkhah A. Biodegradable composite scaffold for repairing defects in load-bearing bones. U.S. Patent Application 20140277578A1, September 18, 2014.Google Scholar

  • [16] Mohammadkhah A. Bioactive glass/polymer composites for bone andnerve repair and regeneration. PhD Thesis, Missouri University of Science and Technology, 2014.Google Scholar

  • [17] Korsunsky A. M. Elastic behavior of materials: continuum effects. In: Encyclopedia of Materials: Science and Technology, 2nd edition, Elsevier, 2001; p. 2398-2404.Google Scholar

About the article

Received: 2017-06-21

Accepted: 2017-11-12

Published Online: 2017-11-30

Published in Print: 2017-11-27


Citation Information: Biomedical Glasses, Volume 3, Issue 1, Pages 86–95, ISSN (Online) 2299-3932, DOI: https://doi.org/10.1515/bglass-2017-0008.

Export Citation

© 2017. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

Comments (0)

Please log in or register to comment.
Log in