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Biomedical Glasses

Editor-in-Chief: Boccaccini, Aldo R.

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Influence of dissolution products of a novel Ca-enriched silicate bioactive glass-ceramic on VEGF release from bone marrow stromal cells

Preethi Balasubramanian
  • Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
  • Other articles by this author:
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/ Rainer Detsch
  • Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Leticia Esteban-Tejeda / Alina Grünewald
  • Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
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  • De Gruyter OnlineGoogle Scholar
/ José S. Moya / Aldo R. Boccaccini
  • Corresponding author
  • Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
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  • Other articles by this author:
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Published Online: 2017-12-29 | DOI: https://doi.org/10.1515/bglass-2017-0010

Abstract

This study evaluated the influence of ionic dissolution products of a novel Ca-enriched silicate bioactive glass compared to commercial available hydroxyapaptite samples (Endobonr) on cell activity and vascular endothelial growth factor (VEGF) release in vitro. Bone marrow stromal cells (ST-2) were cultivated with the supernatant of granules of different sizes and at different concentrations (0-1 wt/vol % of granules) for 48 h. In addition to in vitro studies, Ca-ion release from all as cell morphology observation revealed no cytotoxic effect of the released products from all tested materials. It was found that supernatants from granules in concentrations of 1 wt/vol %enhanced the VEGF release from ST2 cells, which is important as a marker of the vascularisation ability of the glass during the bone healing process.

Keywords : bioactive glasses; angiogenesis; VEGF; ion release

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About the article

Received: 2017-07-30

Revised: 2017-11-22

Accepted: 2017-11-28

Published Online: 2017-12-29

Published in Print: 2017-12-20


Citation Information: Biomedical Glasses, Volume 3, Issue 1, Pages 104–110, ISSN (Online) 2299-3932, DOI: https://doi.org/10.1515/bglass-2017-0010.

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Preethi Balasubramanian, Antonio J. Salinas, Sandra Sanchez-Salcedo, Rainer Detsch, Maria Vallet-Regi, and Aldo R. Boccaccini
Journal of Non-Crystalline Solids, 2018

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