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Biomedical Glasses

Editor-in-Chief: Boccaccini, Aldo R.

CiteScore 2018: 2.05

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Polycaprolactone / bioactive glass hybrid scaffolds for bone regeneration

Cédric Bossard
  • Corresponding author
  • Université Clermont Auvergne, CNRS/IN2P3, Laboratoire de Physique de Clermont, Clermont-Ferrand, France
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Henri Granel
  • Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France
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  • De Gruyter OnlineGoogle Scholar
/ Yohann Wittrant
  • Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France
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/ Édouard Jallot / Jonathan Lao / Christophe Vial / Hanna Tiainen
  • Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Geitmyrsveien, Oslo, Norway
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-12-05 | DOI: https://doi.org/10.1515/bglass-2018-0010


Bioactive glasses (BG) bond to bone and stimulate bone regeneration, but they are brittle. Inorganicorganic hybrids appear as promising bone substitutes since they associate the bone mineral forming ability of BG with the toughness of polymers. Hybrids comprised of polycaprolactone (PCL) and SiO2-CaO BG were produced by sol-gel chemistry and processed into porous scaffolds with controlled pore and interconnection sizes. The obtained scaffolds are highly flexible, meaning that PCL effectively introduces toughness. Apatite formation is observed within 24 hours of immersion in simulated body fluid (SBF) and is not limited to the surface as the entire hybrid progressively changes into bone-like minerals. The degradation rate is suitable for bone regeneration with a 13.2% weight loss after 8 weeks of immersion. Primary osteoblasts cultured in scaffolds demonstrate that the samples are not cytotoxic and provide good cell adhesion. The in vivo study confirms the bioactivity, biocompatibility and suitable degradation rate of the hybrid. A physiological bone made of trabeculae and bone marrow regenerates. The structure and kinetic of bone regeneration was similar to the implanted commercial standard based on bovine bone, demonstrating that this new synthetic PCL-BG hybrid could perform as well as animal-derived bone substitutes.

Keywords: Bioactive glass; Polycaprolactone; Hybrid; Scaffold; Synthetic bone substitute


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About the article

Received: 2018-08-31

Accepted: 2018-11-10

Published Online: 2018-12-05

Published in Print: 2018-11-01

Citation Information: Biomedical Glasses, Volume 4, Issue 1, Pages 108–122, ISSN (Online) 2299-3932, DOI: https://doi.org/10.1515/bglass-2018-0010.

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© by Cédric Bossard, et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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