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Biometrical Letters

The Journal of Polish Biometric Society

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1896-3811
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Comparison of clinical data based on limits of agreement

Luís M. Grilo
  • Corresponding author
  • Unidade Departamental de Matemática, Instituto Politécnico de Tomar, Estrada da Serra - Quinta do Contador, 2300-313 Tomar, Portugal
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/ Helena L. Grilo
  • Corresponding author
  • Unidade Departamental de Matemática, Instituto Politécnico de Tomar, Estrada da Serra - Quinta do Contador, 2300-313 Tomar, Portugal
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-08-17 | DOI: https://doi.org/10.2478/bile-2013-0003

Summary

Two different medical measurement methods, which usually do not produce exactly the same results, are used to analyse the serum levels of folic acid in a blood sample. We assess the (dis)agreement of the available data in order to replace the old method (the reference method, which involves a lot of human intervention) with the new one (which uses mostly machines), without causing problems in clinical interpretation. The 95% limits of agreement are estimated, before and after a logarithmic transformation, and an appropriate use of regression and a nonparametric approach are also considered. The application of these different statistical techniques is very useful and easily interpreted by medical researchers, but the results obtained do not provide confidence that the new method can be used in place of the old one for clinical purposes.

Keywords : Measurement methods; graphical techniques; logarithm transformation; regression approach; nonparametric approach

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About the article

Published Online: 2013-08-17

Published in Print: 2012-06-01


Citation Information: Biometrical Letters, Volume 49, Issue 1, Pages 45–56, ISSN (Print) 1896-3811, DOI: https://doi.org/10.2478/bile-2013-0003.

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