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Open Life Sciences

formerly Central European Journal of Biology

Editor-in-Chief: Ratajczak, Mariusz

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Volume 1, Issue 3


Volume 10 (2015)

PRRs in pathogen recognition

Satoshi Uematsu
  • Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, 565-0871, Japan
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/ Shizuo Akira
  • Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, 565-0871, Japan
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Published Online: 2006-09-01 | DOI: https://doi.org/10.2478/s11535-006-0024-4


The innate immune system provides the first line of host defense against invading microorganisms before the development of adaptive immune responses. Innate immune responses are initiated by germline-encoded pattern recognition receptors (PRRs), which recognize specific structures of microorganisms. Toll-like receptors (TLRs) are pattern-recognition receptors that sense a wide range of microorganisms, including bacteria, fungi, protozoa and viruses. TLRs exist either on the cell surface or in the lysosome/endosome compartment and induce innate immune responses. Recently, cytoplasmic PRRs have been identified which detect pathogens that have invaded the cytosol. This review focuses on the pathogen recognition of PRRs in innate immunity.

Keywords: TLR; NLR; RIG-I

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Published Online: 2006-09-01

Published in Print: 2006-09-01

Citation Information: Open Life Sciences, Volume 1, Issue 3, Pages 299–313, ISSN (Online) 2391-5412, DOI: https://doi.org/10.2478/s11535-006-0024-4.

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