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Open Life Sciences

formerly Central European Journal of Biology

Editor-in-Chief: Ratajczak, Mariusz


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Volume 1, Issue 3

Issues

Volume 10 (2015)

Phenotypic characterisation of extreme growth-selected mouse lines: An important prerequisite for future QTL analysis

Ulla Renne / Gerhard Dietl / Martina Langhammer / Charlotte Rehfeldt / Karin Nürnberg / Siegfried Kuhla / Lutz Bünger
  • SAC, Sustainable Livestock Systems Group, Sir Stephen Watson Building, Bush Estate, Penicuik, Midlothian, EH26 0PH, UK
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Published Online: 2006-09-01 | DOI: https://doi.org/10.2478/s11535-006-0026-2

Abstract

A unique set of seven mouse lines, long-term selected for high growth, from different laboratories around the world has been comprehensively compared to evaluate these resources for future QTL and gene mapping for growth traits. The heaviest line (DUH) was 40% (males) to 44% (females) heavier than the smallest line (ROH) at birth, and 105% (males) to 114% (females) heavier at 98 d. Body conformation (body length and width, body areas), body composition (dry matter, fat, fatty acid composition, organ weights), and skeletal muscle cellularity also differed substantially. DUH was more than 20% longer (12.3 cm) compared to the shortest line ROH (9.7 cm). DAH (22.5%) had the highest percentage of gonadal fat and the leanest was BEH (7.7%). Line BEH (0.49 g) showed the highest weight for the left M. rectus femoris, which was 2.1 times higher, compared to ROH (0.23 g). These results suggest that different alleles, and possibly different physiological pathways, have contributed to the selection response in the different lines. Therefore these selection lines are an important tool with which to identify the genetic and physiological basis of growth as they may contain many, if not all, growth promoting alleles.

Keywords: Mouse; growth; long-term; selection; body conformation; body composition

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Published Online: 2006-09-01

Published in Print: 2006-09-01


Citation Information: Open Life Sciences, Volume 1, Issue 3, Pages 345–375, ISSN (Online) 2391-5412, DOI: https://doi.org/10.2478/s11535-006-0026-2.

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