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Open Life Sciences

formerly Central European Journal of Biology

Editor-in-Chief: Ratajczak, Mariusz

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Volume 2, Issue 2


Volume 10 (2015)

Evolutionary mechanisms of circadian clocks

Guillermo Rodrigo / Javier Carrera / Alfonso Jaramillo
Published Online: 2007-06-01 | DOI: https://doi.org/10.2478/s11535-007-0016-z


An intriguing question in biology is to know how circadian molecular networks could have evolved their particular topologies to adjust to a daily period. We analyze the mechanism of the evolution of such networks by using a computational design strategy that allows for the generation of synthetic networks with a targeted 24 hours oscillation. We have performed a systematic analysis of all possible two-gene network topologies based on a core activator-repressor frequently found in circadian mechanisms. We have considered transcriptional and post-translational regulations to implement this core. We have applied our analysis to both, eukaryotic and prokaryotic circadian machinery. Finally, we conjecture a possible mechanism for the evolution of circadian clocks.

Keywords: Circadian clocks; systems biology; biological networks

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About the article

Published Online: 2007-06-01

Published in Print: 2007-06-01

Citation Information: Open Life Sciences, Volume 2, Issue 2, Pages 233–253, ISSN (Online) 2391-5412, DOI: https://doi.org/10.2478/s11535-007-0016-z.

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© 2007 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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