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formerly Central European Journal of Biology

Editor-in-Chief: Ratajczak, Mariusz

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Volume 2, Issue 2 (Jun 2007)


Evolutionary mechanisms of circadian clocks

Guillermo Rodrigo
  • Depto. de Matematica Aplicada, Universidad Politecnica de Valencia, 46022, Valencia, Spain
  • Email:
/ Javier Carrera
  • Depto. de Matematica Aplicada, Universidad Politecnica de Valencia, 46022, Valencia, Spain
  • Email:
/ Alfonso Jaramillo
  • CNRS — UMR 7654, Ecole Polytechnique, Laboratoire de Biochimie, 91128, Palaiseau, France
  • Email:
Published Online: 2007-06-01 | DOI: https://doi.org/10.2478/s11535-007-0016-z


An intriguing question in biology is to know how circadian molecular networks could have evolved their particular topologies to adjust to a daily period. We analyze the mechanism of the evolution of such networks by using a computational design strategy that allows for the generation of synthetic networks with a targeted 24 hours oscillation. We have performed a systematic analysis of all possible two-gene network topologies based on a core activator-repressor frequently found in circadian mechanisms. We have considered transcriptional and post-translational regulations to implement this core. We have applied our analysis to both, eukaryotic and prokaryotic circadian machinery. Finally, we conjecture a possible mechanism for the evolution of circadian clocks.

Keywords: Circadian clocks; systems biology; biological networks

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About the article

Published Online: 2007-06-01

Published in Print: 2007-06-01

Citation Information: Open Life Sciences, ISSN (Online) 2391-5412, DOI: https://doi.org/10.2478/s11535-007-0016-z. Export Citation

© 2007 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

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