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Open Life Sciences

formerly Central European Journal of Biology

Editor-in-Chief: Ratajczak, Mariusz

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Volume 4, Issue 3


Volume 10 (2015)

Nicotine-induced memory impairment by increasing brain oxidative stress

Lucian Hritcu / Alin Ciobica
  • Department of Biology, “Alexandru Ioan Cuza” University, 700506, Iasi, Romania
  • Laboratory for Experimental and Applied Physiology, Romanian Academy, 700505, Iasi, Romania
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/ Lucian Gorgan
Published Online: 2009-07-26 | DOI: https://doi.org/10.2478/s11535-009-0029-x


Male Wistar rats were subjected to chronic nicotine treatment (0.3 mg/kg; 7 continuous days) and their memory performance was studied by means of Y-maze and multi-trial passive avoidance tasks. Nicotine significantly decreased spontaneous alternation in Y-maze task and step-through-latency in the multi-trial passive avoidance task, suggesting effects on both short-term memory and long-term memory, respectively. In addition, nicotine induced neuronal apoptosis, DNA fragmentation, reduced antioxidant enzymes activity, and increased production of lipid peroxidation and reactive oxygen species, suggesting pro-oxidant activity. Our results provide further support that nicotine-induced memory impairment is due to an increase in brain oxidative stress in rats.

Keywords: Nicotine; Memory; Oxidative stress

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About the article

Published Online: 2009-07-26

Published in Print: 2009-09-01

Citation Information: Open Life Sciences, Volume 4, Issue 3, Pages 335–342, ISSN (Online) 2391-5412, DOI: https://doi.org/10.2478/s11535-009-0029-x.

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