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Open Life Sciences

formerly Central European Journal of Biology

Editor-in-Chief: Ratajczak, Mariusz


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Volume 6, Issue 5

Issues

Volume 10 (2015)

ATP binding cassette systems: structures, mechanisms, and functions

Anke Licht / Erwin Schneider
Published Online: 2011-09-02 | DOI: https://doi.org/10.2478/s11535-011-0054-4

Abstract

ATP-binding cassette (ABC) systems are found in all three domains of life and in some giant viruses and form one of the largest protein superfamilies. Most family members are transport proteins that couple the free energy of ATP hydrolysis to the translocation of solutes across a biological membrane. The energizing module is also used to drive non-transport processes associated, e.g., with DNA repair and protein translation. Many ABC proteins are of considerable medical importance. In humans, dysfunction of at least eighteen out of 49 ABC transporters is associated with disease, such as cystic fibrosis, Tangier disease, adrenoleukodystrophy or Stargardt’s macular degeneration. In prokaryotes, ABC proteins confer resistance to antibiotics, secrete virulence factors and envelope components, or mediate the uptake of a large variety of nutrients. Canonical ABC transporters share a common structural organization comprising two transmembrane domains (TMDs) that form the translocation pore and two nucleotide-binding domains (NBDs) that bind and hydrolyze ATP. In this Mini-Review, we summarize recent structural and biochemical data obtained from both prokaryotic and eukaryotic model systems.

Keywords: ATP-binding cassette; Protein superfamily; Transport proteins; P-glycoprotein; Maltose transporter; ECF transporter; Prokaryotes; Eukaryotes; Disease

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About the article

Published Online: 2011-09-02

Published in Print: 2011-10-01


Citation Information: Open Life Sciences, Volume 6, Issue 5, Pages 785–801, ISSN (Online) 2391-5412, DOI: https://doi.org/10.2478/s11535-011-0054-4.

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BMC Plant Biology, 2015, Volume 15, Number 1, Page 51
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Acta Crystallographica Section F Structural Biology Communications, 2015, Volume 71, Number 2, Page 189
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Chemosphere, 2015, Volume 124, Page 143
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Computational Biology and Chemistry, 2015, Volume 54, Page 18
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FEBS Journal, 2014, Volume 281, Number 1, Page 331
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014, Volume 1838, Number 1, Page 106
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013, Volume 1828, Number 9, Page 2164
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Drug Discovery Today, 2013, Volume 18, Number 5-6, Page 218
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Molecular Microbiology, 2012, Volume 86, Number 4, Page 908

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