[1] Tena-Sempere M., KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility, Neuroendocrinol., 2006, 83, 275–281 http://dx.doi.org/10.1159/000095549CrossrefGoogle Scholar

[2] Lee D.K., Nguyen T., O’Neill G.P., Cheng R., Liu Y., Howard A.D., et al., Discovery of a receptor related to the galanin receptors, FEBS Letter, 1999, 446, 103–107 http://dx.doi.org/10.1016/S0014-5793(99)00009-5CrossrefGoogle Scholar

[3] West A., Vojta P.J., Welch D.R., Weissman B.E, Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1), Genomics., 1998, 54, 145–148 http://dx.doi.org/10.1006/geno.1998.5566CrossrefGoogle Scholar

[4] Lee J.H., Miele M.E., Hicks D.J., Phillips K.K., Trent J.M., Weissman B.E., et al., KiSS-1, a novel human malignant melanoma metastasis-suppressor gene, J Natl Cancer Inst., 1996, 88, 1731–1737. http://dx.doi.org/10.1093/jnci/88.23.1731CrossrefGoogle Scholar

[5] Ohtaki T., Shintani Y., Honda S., Matsumoto H., Hori A., Kanehashi K., et al., Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor, Nature, 2001, 411, 613–617 http://dx.doi.org/10.1038/35079135CrossrefGoogle Scholar

[6] Kotani M., Detheux M., Vandenbogaerde A., Communi D., Vanderwinden J.M., Le Poul E., et al., The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G proteincoupled receptor GPR54, J Biol Chem., 2001, 276, 34631–34636 http://dx.doi.org/10.1074/jbc.M104847200CrossrefGoogle Scholar

[7] Muir A.I., Chamberlain L., Elshourbagy N.A., Michalovich D., Moore D.J., Calamari A., et al., AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1, J Biol Chem., 2001, 276, 28969–28975 http://dx.doi.org/10.1074/jbc.M102743200Google Scholar

[8] Gottsch M.L., Cunningham M.J., Smith J.T., Popa S.M., Acohido B.V., Crowley W.F., et al., A role for kisspeptins in the regulation of gonadotropin secretion in the mouse, Endocrinology., 2004, 145, 4073–4077 http://dx.doi.org/10.1210/en.2004-0431CrossrefGoogle Scholar

[9] Clarkson J., Herbison A.E., Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons, Endocrinology., 2006, 147, 5817–5825 http://dx.doi.org/10.1210/en.2006-0787CrossrefGoogle Scholar

[10] De Roux N., Genin E., Carel J.C., Matsuda F., Chaussain J.L., Milgrom E., Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54? PNAS USA, 2003, 10972–10976 Google Scholar

[11] Seminara S.B., Messager S., Chatzidaki E.E., Thresher R.R., Acierno J.R., Shagoury J.K., et al., The GPR54 gene as a regulator of puberty, N. Engl. J. Med., 2003, 349, 1614–1627 http://dx.doi.org/10.1056/NEJMoa035322CrossrefGoogle Scholar

[12] Oakley A.E., Clifton D.K., Steiner R.A., Kisspeptin signaling in the Brain, Endocr Rev., 2009, 30, 713–743 http://dx.doi.org/10.1210/er.2009-0005CrossrefGoogle Scholar

[13] Messager S., Chatzidaki E.E., Ma D., Hendrick A.G., Zahn D., Dixon J., et al., Kisspeptin directly stimulates gonadotropin releasing hormone release via G protein coupled receptor 54, PNAS USA, 2005, 102, 1761–1766 http://dx.doi.org/10.1073/pnas.0409330102CrossrefGoogle Scholar

[14] Smith J.T., Li Q., Yap K.S., Shahab M., Roseweir A.K., Millar R.P., et al., Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence, Endocrinology, 2011, 152, 1001–1012 http://dx.doi.org/10.1210/en.2010-1225CrossrefGoogle Scholar

[15] Han S.K., Gottsch M.L., Lee K.J., Popa S.M., Smith J.T., Jakawich S.K., et al., Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty, J Neurosci., 2005, 25, 11349–11356 http://dx.doi.org/10.1523/JNEUROSCI.3328-05.2005CrossrefGoogle Scholar

[16] Irwig M.S., Fraley G.S., Smith J.T., Acohido B.V., Popa S.M., Cunningham M.J., et al., Kisspeptin activation of gonadotropin releasing neurons and regulation of KiSS1mRNA in the male rat, Neuroendocrinol., 2004, 80, 264–272 http://dx.doi.org/10.1159/000083140CrossrefGoogle Scholar

[17] Castellano J.M., Gaytan M., Roa J., Vigo E., Navarro V.M., Bellido C., et al., Expression of KiSS-1 in rat ovary: Putative local regulator of ovulation, Endocrinology, 2006, 147, 4852–4862 http://dx.doi.org/10.1210/en.2006-0117CrossrefGoogle Scholar

[18] Pinto F., Cejudo-Román A., Ravina C., Fernández-Sánchez M., Martín-Lozano D., Illanes M., et al., Characterization of the kisspeptin system in human spermatozoa, Intel. J. Androl., 2011, 35, 63–73 http://dx.doi.org/10.1111/j.1365-2605.2011.01177.xCrossrefGoogle Scholar

[19] Ramaswamy S., Seminara S.B., Pohl C.R., DiPietro M.J., Crowley J.W., Plant T.M., et al., Effect of continuous intravenous administration of human metastin 45–54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta), Endocrinology, 2007, 148, 3364–3370 http://dx.doi.org/10.1210/en.2007-0207CrossrefGoogle Scholar

[20] Skinner K.M., Norton N.J., Mullaney P.B., Rosselli M., Whaley D.P., Anthony T.C., Cell-cell interactions and the regulation of testis function, Ann N Y Acad Sci., 1991, 637, 354–363 http://dx.doi.org/10.1111/j.1749-6632.1991.tb27322.xCrossrefGoogle Scholar

[21] Sofikitis N., Pappas E., Kawatani A., Baltogiannis D., Loutradis D., Kanakas N., et al., Efforts to create an artificial testis: culture systems of male germ cells under biochemical conditions resembling the seminiferous tubular biochemical environment, Hum Reprod Update, 2005, 11, 229–259 http://dx.doi.org/10.1093/humupd/dmi007CrossrefGoogle Scholar

[22] Huleihel M., Lunenfeld E., Regulation of spermatogenesis by paracrine/autocrine testicular factors, Asian. J. Androl., 2004, 6, 259–268 Google Scholar

[23] Skinner K.M., Growth Factors in Gonadal Development, J. Animal. Sci., 1992, 70, 30–41 Google Scholar

[24] Skinner K.M., Nilsson E.E., Bhandari K.R., Cell — Cell signaling in the testis and ovary, In: Edward A.D., Ralph A.B., (Eds.), Handbook of cell signaling, 2nd ed., Academic Press, 2009 Google Scholar

[25] Huleihel M., Lunenfeld E., Involvement of intratesticular IL-1 system in the regulation of Sertoli cell functions, Mol. Cell. Endocrinol., 2002, 187, 125–132 http://dx.doi.org/10.1016/S0303-7207(01)00690-6CrossrefGoogle Scholar

[26] Ogawa K., Hasshimoto O., Kurohmaru M., Mizutani T., Sugino H., Hayashi Y., Folllistatin like immunoreactivitiy in the cytoplasm and nucleus of spermatogenic cells in the rats, Euro. J. Endocrinol., 1997, 137, 523–529 http://dx.doi.org/10.1530/eje.0.1370523CrossrefGoogle Scholar

[27] Meinhardt A., O’Bryan M.K., McFarlane J.R., Loveland K.L., Mallidis C., Foulds L.M., et al., Localization of follistatin in the rat testis, J. Reprod. Fertil., 1998, 112, 233–241 http://dx.doi.org/10.1530/jrf.0.1120233CrossrefGoogle Scholar

[28] Terada N., Ohno N., Saitoh S., Saitoh Y., Komada M., Kubota H., et al., Involvement of a membrane skeletal protein, 4.1G, for Sertoli/germ cell interaction, Reproduction, 2010, 139, 883–892 http://dx.doi.org/10.1530/REP-10-0005CrossrefGoogle Scholar