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Open Life Sciences

formerly Central European Journal of Biology

Editor-in-Chief: Ratajczak, Mariusz


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Volume 8, Issue 7

Issues

Volume 10 (2015)

Ras and Ras mutations in cancer

Satish Rajasekharan
  • Anusandhan Kendra, SASTRA’s Hub for Research & Innovation, SASTRA University, Thanjavur, 613 401, Tamil Nadu, India
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/ Thiagarajan Raman
  • Department of Bioengineering, School of Chemical and Biotechnology, SASTRA University, Thanjavur, 613 401, Tamil Nadu, India
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Published Online: 2013-04-23 | DOI: https://doi.org/10.2478/s11535-013-0158-5

Abstract

Ras genes are pre-eminent genes that are frequently linked with cancer biology. The functional loss of ras protein caused by various point mutations within the gene, is established as a prognostic factor for the genesis of a constitutively active Ras-MAPK pathway leading to cancer. Ras signaling circuit follows a complex pathway, which connects many signaling molecules and cells. Several strategies have come up for targeting mutant ras proteins for cancer therapy, however, the clinical benefits remain insignificant. Targeting the Ras-MAPK pathway is extremely complicated due its intricate networks involving several upstream and downstream regulators. Blocking oncogenic Ras is still in latent stage and requires alternative approaches to screen the genes involved in Ras transformation. Understanding the mechanism of Ras induced tumorigenesis in diverse cancers and signaling networks will open a path for drug development and other therapeutic approaches.

Keywords: Ras; Cancer; Signaling; MAPK pathway; Oncogene

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About the article

Published Online: 2013-04-23

Published in Print: 2013-07-01


Citation Information: Open Life Sciences, Volume 8, Issue 7, Pages 609–624, ISSN (Online) 2391-5412, DOI: https://doi.org/10.2478/s11535-013-0158-5.

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