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Open Life Sciences

formerly Central European Journal of Biology

Editor-in-Chief: Ratajczak, Mariusz


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Volume 8, Issue 7

Issues

Volume 10 (2015)

Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Danut Cimponeriu / Cristian Serafinceanu / Pompilia Apostol / Mihai Toma / Monica Stavarachi / Irina Radu / Anne Craciun / Sonia Spandole / Panduru Nicolae / Lavinia Rusu / Oana Schiopu / Daniela Ion
Published Online: 2013-04-23 | DOI: https://doi.org/10.2478/s11535-013-0178-1

Abstract

Polymorphisms in IL6, ACE and ATR genes are associated with obesity. Torque Teno virus (TTV) seems to be able to interfere with production of some proinflammatory cytokines associated with obesity and related phenotypes. The aim of this study was to test the potential association between obesity, TTV infection and the IL6 G-174C (rs1800795), ACE I/D (rs4646994), AT1R A1166C (rs5186) polymorphisms. The polymorphisms and the presence of TTV were detected in blood samples from 150 obese and 150 normal-weight, healthy subjects using PCR based methods. IL6-174 CC genotype was more frequent in all obese patients (P=0.02) and in patients without TTV infections (P=0.03) than in controls. Obese women had more frequent TTV infections compared with normal-weight women (P=0.046). Obese subjects, regardless of gender (women P=0.03, men P=0.04), and healthy normal-weight men (P<0.01) carriers of AT1R C allele had higher triglycerides levels compared with non-carriers. The frequency of TTV in the control group (70.67%) was similar to data reported in other populations. The present study indicated that IL6-174 CC genotype and TTV infections in women could be associated with the common form of obesity.

Keywords: Obesity; IL6; ACE; AT1R; Polymorphisms; TTV

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About the article

Published Online: 2013-04-23

Published in Print: 2013-07-01


Citation Information: Open Life Sciences, Volume 8, Issue 7, Pages 625–632, ISSN (Online) 2391-5412, DOI: https://doi.org/10.2478/s11535-013-0178-1.

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