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Open Life Sciences

formerly Central European Journal of Biology

Editor-in-Chief: Ratajczak, Mariusz


IMPACT FACTOR 2018: 0.504
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Open Access
Online
ISSN
2391-5412
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Volume 10, Issue 1

Issues

Volume 10 (2015)

Negative association between paraoxonase 2, anthropometric markers and metabolic syndrome

Andrada Mihai
  • University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • NIDNMD “Prof. N.C. Paulescu”, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Daniela Lixandru
  • University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • Institute of Biochemistry of the Romanian Academy, Molecular Cell Biology Department, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Petruta Alexandru
  • University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • Institute of Biochemistry of the Romanian Academy, Molecular Cell Biology Department, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Irina Stoian / Simona Carniciu
  • University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • NIDNMD “Prof. N.C. Paulescu”, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Manuela Mitu
  • University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • NIDNMD “Prof. N.C. Paulescu”, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Cristian Guja
  • University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • NIDNMD “Prof. N.C. Paulescu”, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Constantin Ionescu-Tirgoviste
  • University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • NIDNMD “Prof. N.C. Paulescu”, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-08-19 | DOI: https://doi.org/10.1515/biol-2015-0037

Abstract

Background Metabolic syndrome (MS) has a great impact on cardiovascular mortality and morbidity. Our aim was to investigate the association of MS with some oxidant and antioxidant markers, including pro-and antioxidant status of peripheral blood mononuclear cells (PBMC) in newly diagnosed type 2 diabetic mellitus patients (ND-T2D). Methods 219 ND-T2D and 88 healthy subjects were divided in two groups according to the absence or presence of MS. Anthropometric measurements, routine blood tests, total oxidant status (TOS), total antioxidant status (TAS) and ELISA measurements were included. The PBMC capacity to release free radicals and to neutralize them was also determined by measuring the respiratory burst (RB) together with the lactonase activity of the intracellular antioxidant enzyme paraoxonase 2 (PON2). Results Comparing ND-T2D MS+ with those MS- the RB of the PBMC was significantly higher (p<0.05) while lactonase PON2 enzymatic activity was decreased (p < 0.001). A negative correlation of RB was found with TAS (r = -0.416, p < 0.05). PON2 was also negatively correlated with glycaemia (r = -0.275, p < 0.001), HbA1c (r = -0.308, p < 0.001), weight (r = -0.183; p < 0.05), waist circumference (r = -0.353, p < 0.001) and body mass index (r = -0.290, p < 0.001). Conclusion PON2 lactonase activity is negatively associated with anthropometric markers in ND-T2D with MS.

Keywords: type 2 diabetes; metabolic syndrome; paraoxonase 2; total oxidant and antioxidant status

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About the article

Received: 2015-01-18

Accepted: 2015-05-11

Published Online: 2015-08-19


Citation Information: Open Life Sciences, Volume 10, Issue 1, ISSN (Online) 2391-5412, DOI: https://doi.org/10.1515/biol-2015-0037.

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©2015 Andrada Mihai, et al.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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