Skip to content
BY-NC-ND 3.0 license Open Access Published by De Gruyter June 1, 2007

Bioactive secondary metabolites produced by microorganisms associated with plants

  • Silvia Firáková EMAIL logo , Mária Šturdíková and Marta Múčková
From the journal Biologia

Abstract

In the past few decades groups of scientists have focused their study on relatively new microorganisms called endophytes. By definition these microorganisms, mostly fungi and bacteria, colonise the intercellular spaces of the plant tissues. The mutual relationship between endophytic microorganisms and their host plants, taxanomy and ecology of endophytes are being studied. Some of these microorganisms produce bioactive secondary metabolites that may be involved in a host-endophyte relationship. Recently, many endophytic bioactive metabolites, known as well as new substances, possesing a wide variety of biological activities as antibiotic, antitumor, antiinflammatory, antioxidant, etc. have been identified. The microorganisms such as endophytes may be very interesting for biotechnological production of bioactive substances as medicinally important agents. Therefore the aim of this review is to briefly characterize endophytes and summarize the structuraly different bioactive secondary metabolites produced by endophytic microorganisms as well as microbial sources of these metabolites and their host plants.

[1] Araújo W.L., Maccheroni W.Jr., Aguilar-Vildoso C.I., Barroso P.A., Saridakis H.O. & Azevedo J.L. 2001. Can. J. Microbiol. 47: 229–236. http://dx.doi.org/10.1139/cjm-47-3-22910.1139/cjm-47-3-229Search in Google Scholar

[2] Barz W., Daniel S., Hinderer W., Jaques U., Kessmann H., Koster J. & Tiemann K. 1988. In: Pais M., Mavituna F. & Novais J. (eds), Plant Cell Biotechnology, Springer (NATO ASI series), Berlin, Heidelberg, New York, pp. 211–213. Search in Google Scholar

[3] Brady S.F., Wagenaar M.M., Singh M.P., Janso J.E. & Clardy J. 2000. Org. Lett. 14: 4043–4046. http://dx.doi.org/10.1021/ol006680s10.1021/ol006680sSearch in Google Scholar

[4] Castillo U.F., Strobel G.A., Ford E.J., Hess W.M., Porter H., Jensen J.B., Albert H., Robison R., Condron M.A.M., Teplow D.B., Stevens D. & Yaver, D. 2002. Microbiol. 148: 2675–2685. 10.1099/00221287-148-9-2675Search in Google Scholar

[5] Castillo U., Harper J.K., Strobel G.A., Sears J., Alesi K., Ford E., Lin J., Hunter M., Maranta M., Ge H., Yaver D., Jensen J.B., Porter H., Robison R., Millar D., Hess W. M., Condron M. & Teplow D. 2003. FEMS Microbiol. Lett. 224: 183–190. http://dx.doi.org/10.1016/S0378-1097(03)00426-910.1016/S0378-1097(03)00426-9Search in Google Scholar

[6] Coombs J.T., Michelsen P.P. & Franco C.M.M. 2004. Biol. Control 29: 359–366. http://dx.doi.org/10.1016/j.biocontrol.2003.08.00110.1016/j.biocontrol.2003.08.001Search in Google Scholar

[7] Dos Santos R. & Rodrigues-Fo E. 2003. Z. Naturforsch. 58c: 663–669. 10.1515/znc-2003-9-1012Search in Google Scholar

[8] Ezra D., Castillo U.F., Strobel G.A., Hess W.M., Porter H., Jensen J.B., Condron M.A., Teplow D.B., Sears J., Maranta M., Hunter M., Weber B. & Yaver D. 2004. Microbiol. 150: 785–793. http://dx.doi.org/10.1099/mic.0.26645-010.1099/mic.0.26645-0Search in Google Scholar

[9] Fábio A., Proença B. & Edson R.F. 2005. Biochem. Syst. Ecol. 33: 257–268. http://dx.doi.org/10.1016/j.bse.2004.09.00210.1016/j.bse.2004.09.002Search in Google Scholar

[10] Germaine K., Keogh E., Garcia-Cabellos G., Borremans B., van der Lelie D., Barac T., Oeyen L., Vangronsveld J., Porteous Moore F., Moore E.R.B., Campbell C.D., Ryan D. & Dowling D.N. 2004. FEMS Microbiol. Ecol. 48: 109–118. http://dx.doi.org/10.1016/j.femsec.2003.12.00910.1016/j.femsec.2003.12.009Search in Google Scholar

[11] Harper J.K., Arif A.M., Ford E.J., Strobel G.A., Porco J.A., Tomer D.P., Oneill K.L., Heider E.M. & Grant D.M. 2003. Tetrahedron 59: 2471–2476. http://dx.doi.org/10.1016/S0040-4020(03)00255-210.1016/S0040-4020(03)00255-2Search in Google Scholar

[12] Hormazabal E., Schmeda-Hirschmann G., Astudillo L., Rodriguez J. & Theoduloz C. 2005. Z. Naturforsch [C] 60: 11–21. 10.1515/znc-2005-1-203Search in Google Scholar

[13] Jadulco R., Brauers G., Edrada R.A., Ebel R., Wray V., Sudarsono V. & Proksch P. 2002. J. Nat. Prod. 65: 730–733. http://dx.doi.org/10.1021/np010390i10.1021/np010390iSearch in Google Scholar

[14] Janssen G.B., Beems R.B., Speijers G.J. & van Egmond H.P. 2000. Food Chem. Toxicol. 38: 679–688. http://dx.doi.org/10.1016/S0278-6915(00)00054-510.1016/S0278-6915(00)00054-5Search in Google Scholar

[15] Kingston D.G.I. 2001. Chem. Commun. 867–880. 10.1039/b100070pSearch in Google Scholar

[16] Klemke C., Kehraus S., Wright A.D. & Konig G.M. 2004. J. Nat. Prod. 67: 1058–1053. http://dx.doi.org/10.1021/np034061x10.1021/np034061xSearch in Google Scholar

[17] Krohn K., Biele C., Drogies K.H., Steingrover K., Aust H.J., Draeger S. & Schulz B. 2002. Eur. J. Org. Chem. 2002: 2331–2336. http://dx.doi.org/10.1002/1099-0690(200207)2002:14<2331::AID-EJOC2331>3.0.CO;2-P10.1002/1099-0690(200207)2002:14<2331::AID-EJOC2331>3.0.CO;2-PSearch in Google Scholar

[18] Kumar D.S., Lau S.C., Van J.M., Yang D. & Hyde K.D. 2005. Life Sci. 78: 147–156. http://dx.doi.org/10.1016/j.lfs.2005.04.05010.1016/j.lfs.2005.04.050Search in Google Scholar

[19] Kunkel B.A., Grewal P.S. & Quigley M.F. 2004. Biol. Control 29: 100–108. http://dx.doi.org/10.1016/S1049-9644(03)00119-110.1016/S1049-9644(03)00119-1Search in Google Scholar

[20] Leuchtmann A., Petrini O., Petrini L.E. & Carroll G.C. 1992. Mycol. Res. 96: 287–294. 10.1016/S0953-7562(09)80940-4Search in Google Scholar

[21] Li J.Y., Harper J.K., Grant D.M., Tombe B.O., Bashyal B., Hess W.M. & Strobel G.A. 2001. Phytochem. 56: 463–468. http://dx.doi.org/10.1016/S0031-9422(00)00408-810.1016/S0031-9422(00)00408-8Search in Google Scholar

[22] Li J.Y. & Strobel G.A. 2001. Phytochem. 57: 261–265. http://dx.doi.org/10.1016/S0031-9422(01)00021-810.1016/S0031-9422(01)00021-8Search in Google Scholar

[23] Li H.M., Sullivan R., Moy M., Kobayashi D.Y. & Belanger F.C. 2004. Mycologia 96: 526–536. 10.1080/15572536.2005.11832951Search in Google Scholar

[24] Liu J.Y., Song Y.C., Zhang Z., Wang L., Guo Z.J., Zou W.X. & Tan R.X. 2004. J. Biotechnol. 114: 279–287. http://dx.doi.org/10.1016/j.jbiotec.2004.07.00810.1016/j.jbiotec.2004.07.008Search in Google Scholar PubMed

[25] Ma Y.M., Li Y., Liu J.Y., Song Y.C. & Tan R.X. 2004. Fitoterapia 75: 451–456. http://dx.doi.org/10.1016/j.fitote.2004.03.00710.1016/j.fitote.2004.03.007Search in Google Scholar PubMed

[26] Mercier J. & Jiménez J.I. 2004. Postharvest Biol. Technol. 31: 1–8. http://dx.doi.org/10.1016/j.postharvbio.2003.08.00410.1016/j.postharvbio.2003.08.004Search in Google Scholar

[27] Moy M., Li H.J.M., Sullivan R., White J.F. & Belanger F.C. 2002. Plant Physiol. 130: 1298–1308. http://dx.doi.org/10.1104/pp.01010810.1104/pp.010108Search in Google Scholar PubMed PubMed Central

[28] Ohzeki T. & Mori K. 2003. Biosci. Biotechnol. Biochem. 67: 2584–2590. http://dx.doi.org/10.1271/bbb.67.258410.1271/bbb.67.2584Search in Google Scholar PubMed

[29] Park J.H., Choi G.J., Lee H.B., Kim K.M., Jung H.S., Lee S.W., Jang K.S., Cho K.Y. & Kim J.C. 2005. J. Microbiol. Biotechnol. 15: 112–117. Search in Google Scholar

[30] Petrini L.E., Petrini O., Leuchtmann A. & Carroll G.C. 1991. Sydowia 43: 148–169. Search in Google Scholar

[31] Petrini O., Sieber T.N., Toti L. & Viret O. 1992. Nat. Toxins 1: 185–196. http://dx.doi.org/10.1002/nt.262001030610.1002/nt.2620010306Search in Google Scholar PubMed

[32] Puri S.C., Nazir A., Chawla R., Arora R., Ryiaz-ul-Hasan S., Amna T., Ahmed B., Verma V., Singh S., Sagar R., Sharma A., Kumar R., Sharma R.K. & Quazi G.N. 2006. J. Biotechnol. (in press) Search in Google Scholar

[33] Puri S.C., Verma V., Amna T., Quazi G.N. & Spiteller M. 2005. J. Nat. Prod. 68: 1717–1719. http://dx.doi.org/10.1021/np050280210.1021/np0502802Search in Google Scholar PubMed

[34] Read D.J., Ducket J.G., Francis R., Ligron R. & Russell A. 2000. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 355: 815–830. http://dx.doi.org/10.1098/rstb.2000.061710.1098/rstb.2000.0617Search in Google Scholar PubMed PubMed Central

[35] Saikkonen K., Wäli P., Helander M. & Taeth S.H. 2004. Trends Plant Sci. 9: 275–280. http://dx.doi.org/10.1016/j.tplants.2004.04.00510.1016/j.tplants.2004.04.005Search in Google Scholar

[36] Salituro G.M, Pelaez F. & Zhang B.B. 2001. Recent Prog. Horm. Res. 56: 107–126. http://dx.doi.org/10.1210/rp.56.1.10710.1210/rp.56.1.107Search in Google Scholar

[37] Schardl C.L. 2001. Fungal Genet. Biol. 33: 69–82. http://dx.doi.org/10.1006/fgbi.2001.127510.1006/fgbi.2001.1275Search in Google Scholar

[38] Schulz B., Boyle C.H., Draeger S., Rommert A.K. & Krohn K. 2002. Mycol. Res. 106: 996–1004. http://dx.doi.org/10.1017/S095375620200634210.1017/S0953756202006342Search in Google Scholar

[39] Schwarz M., Kopcke B., Weber R.W.S., Sterner O. & Anke H. 2004. Phytochem. 65: 2239–2245. http://dx.doi.org/10.1016/j.phytochem.2004.06.03510.1016/j.phytochem.2004.06.035Search in Google Scholar

[40] Scott B. 2001. Curr. Opin. Microbiol. 4: 393–398. http://dx.doi.org/10.1016/S1369-5274(00)00224-110.1016/S1369-5274(00)00224-1Search in Google Scholar

[41] Sieber T.N., Sieber-Canavesi F. & Dorworth C.E. 1991. Can. J. Bot. 69: 407–411. 10.1139/b91-056Search in Google Scholar

[42] Song Y.C., Li H., Ye Y.H., Shan C.Y., Yang Y.M. & Tan R.X. 2004. FEMS Microbiol. Lett. 241: 67–72. http://dx.doi.org/10.1016/j.femsle.2004.10.00510.1016/j.femsle.2004.10.005Search in Google Scholar

[43] Song Y.C., Huang W.Y., Sun C., Wang F.W. & Tan R.X. 2005. Biol. Pharm. Bull. 28: 506–509. http://dx.doi.org/10.1248/bpb.28.50610.1248/bpb.28.506Search in Google Scholar

[44] Stamford T.L., Stamford N.P., Coelho L.C. & Araujo J.M. 2002. Bioresour. Technol. 83: 105–109. http://dx.doi.org/10.1016/S0960-8524(01)00206-110.1016/S0960-8524(01)00206-1Search in Google Scholar

[45] Strobel G.A., Stierle A., Stierle D. & Hess W.M. 1993. Mycotaxon. 47: 71–78. Search in Google Scholar

[46] Strobel G., Ford E., Worapong J., Harper J.K., Arif A.M., Grant D.M., Fung P.C.W. & Chau R.M.W. 2002. Phytochem. 60: 179–183. http://dx.doi.org/10.1016/S0031-9422(02)00062-610.1016/S0031-9422(02)00062-6Search in Google Scholar

[47] Strobel G.A. 2002. Can. J. Plant Pathol. 24: 14–20. http://dx.doi.org/10.1080/0706066010950696510.1080/07060660109506965Search in Google Scholar

[48] Strobel G.A. 2003. Microbes Infect. 5: 535–544. http://dx.doi.org/10.1016/S1286-4579(03)00073-X10.1016/S1286-4579(03)00073-XSearch in Google Scholar

[49] Strobel G.A. & Daisy B. 2003. Microbiol. Mol. Biol. Rev. 67: 491–502. http://dx.doi.org/10.1128/MMBR.67.4.491-502.200310.1128/MMBR.67.4.491-502.2003Search in Google Scholar

[50] Suto M., Takebayashi M., Saito K., Tanaka M., Yokota A. & Tomita F. 2002. J. Biosci. Bioeng. 93: 88–90. 10.1016/S1389-1723(02)80059-7Search in Google Scholar

[51] Tan R.X. & Zou W.X. 2001. Nat. Prod. Rep. 18: 448–459. http://dx.doi.org/10.1039/b100918o10.1039/b100918oSearch in Google Scholar

[52] Tesar M., Reichenauer T.G. & Sessitsch A. 2002. Soil Biol. Biochem. 34: 1883–1892. http://dx.doi.org/10.1016/S0038-0717(02)00202-X10.1016/S0038-0717(02)00202-XSearch in Google Scholar

[53] Wang J., Machado C., Panaccione D.G., Tsai H.F. & Schardl C.L. 2004. Fungal Genet. Biol. 41: 189–198. http://dx.doi.org/10.1016/j.fgb.2003.10.00210.1016/j.fgb.2003.10.002Search in Google Scholar PubMed

[54] Weber R.W., Stenger E., Meffert A. & Hahn M. 2004a. Mycol. Res. 108: 662–671. http://dx.doi.org/10.1017/S095375620400024310.1017/S0953756204000243Search in Google Scholar

[55] Weber D., Sterner O., Anke T., Gorzalczancy S., Martino V. & Acevedo C. 2004b. J. Antibiot. (Tokyo) 57: 559–563. 10.7164/antibiotics.57.559Search in Google Scholar PubMed

[56] Wiyakrutta S., Sriubolmas N., Panphut W., Thongon N., Danwisetkanjana K., Ruangrungsi N. & Meevootisom V. 2004. World J. Microbiol. Biotechnol. 20: 265–272. http://dx.doi.org/10.1023/B:WIBI.0000023832.27679.a810.1023/B:WIBI.0000023832.27679.a8Search in Google Scholar

[57] Zhao P.J., Fan L.M., Li G.H., Zhu N. & Shen Y.M. 2005. Arch. Pharm. Res. 28: 1228–1232. http://dx.doi.org/10.1007/BF0297820310.1007/BF02978203Search in Google Scholar PubMed

Published Online: 2007-6-1
Published in Print: 2007-6-1

© 2007 Institute of Botany, Slovak Academy of Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Downloaded on 28.3.2024 from https://www.degruyter.com/document/doi/10.2478/s11756-007-0044-1/html
Scroll to top button