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Volume 62, Issue 3


Cytotoxic and genotoxic effects of Lavandula stoechas aqueous extracts

Tülay Çelik / Özlem Aslantürk
Published Online: 2007-06-01 | DOI: https://doi.org/10.2478/s11756-007-0051-2


Lavandula genus is an important member of Labiatae (Lamiaceae) family. People use commonly Lavandula stoechas as a medicinal plant for various diseases around the world and also in Turkey. The aim of this study was to investigate cytotoxic and genotoxic effects of aqueous extracts (40, 80 and 120 g/L) from L. stoechas flowers on Allium cepa root tip meristem cells. For this purpose, A. cepa onion bulbs were treated with the above-mentioned L. stoechas flower extracts for 72 h. Spring water (pH 7.3) was used as a control. The result of this study sowed that aqueous extracts reduced mitotic index, but induced chromosome aberrations and mitotic aberrations in comparison with control, significantly (p < 0.05). Aqueous extracts induced breaks, stickiness, pole deviations and micronuclei. Furthermore, these effects were related to extract concentrations. These results showed that L. stoechas aqueous extracts have cytotoxic and genotoxic effects.

Keywords: Lavandula stoechas L.; plant extract; cytotoxic effect; genotoxic effect; Allium cepa L.

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About the article

Published Online: 2007-06-01

Published in Print: 2007-06-01

Citation Information: Biologia, Volume 62, Issue 3, Pages 292–296, ISSN (Online) 1336-9563, ISSN (Print) 0006-3088, DOI: https://doi.org/10.2478/s11756-007-0051-2.

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© 2007 Institute of Molecular Biology, Slovak Academy of Sciences. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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