Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico


Covered by Web of Science (BIOSIS Previews)

PubMed Indexed

CiteScore 2018: 3.35

SCImago Journal Rank (SJR) 2018: 1.475
Source Normalized Impact per Paper (SNIP) 2018: 0.825

ICV 2018: 124.31

Open Access
Online
ISSN
1868-503X
See all formats and pricing
More options …
Volume 1, Issue 1

Issues

Brain glutaminases

Javier Márquez
  • Departamento de Biología Molecular y Bioquímica, Laboratorio de Química de Proteínas, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mercedes Martín-Rufián
  • Departamento de Biología Molecular y Bioquímica, Laboratorio de Química de Proteínas, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Juan A. Segura
  • Departamento de Biología Molecular y Bioquímica, Laboratorio de Química de Proteínas, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ José M. Matés
  • Departamento de Biología Molecular y Bioquímica, Laboratorio de Química de Proteínas, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ José A. Campos-Sandoval
  • Marie Curie Membrane Proteins Laboratory, Biology Department, National University of Ireland, Maynooth, Co. Kildare, Ireland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Francisco J. Alonso
  • Departamento de Biología Molecular y Bioquímica, Laboratorio de Química de Proteínas, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-03-31 | DOI: https://doi.org/10.1515/bmc.2010.006

Abstract

Glutaminase is considered as the main glutamate producer enzyme in brain. Consequently, the enzyme is essential for both glutamatergic and gabaergic transmissions. Glutamine-derived glutamate and ammonia, the products of glutaminase reaction, fulfill crucial roles in energy metabolism and in the biosynthesis of basic metabolites, such as GABA, proteins and glutathione. However, glutamate and ammonia are also hazardous compounds and danger lurks in their generation beyond normal physiological thresholds; hence, glutaminase activity must be carefully regulated in the mammalian brain. The differential distribution and regulation of glutaminase are key factors to modulate the metabolism of glutamate and glutamine in brain. The discovery of novel isoenzymes, protein interacting partners and subcellular localizations indicate new functions for brain glutaminase. In this short review, we summarize recent findings that point consistently towards glutaminase as a multifaceted protein able to perform different tasks. Finally, we will highlight the involvement of glutaminase in pathological states and its consideration as a potential therapeutic target.

Keywords: astrocytes; glutamate; glutamine; glutaminase-interacting proteins; neurones

About the article

Corresponding author


Published Online: 2010-03-31

Published in Print: 2010-05-01


Citation Information: BioMolecular Concepts, Volume 1, Issue 1, Pages 3–15, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc.2010.006.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Mercedes Martín-Rufián, Marta Tosina, José A. Campos-Sandoval, Elisa Manzanares, Carolina Lobo, J. A. Segura, Francisco J. Alonso, José M. Matés, Javier Márquez, and Maria Gasset
PLoS ONE, 2012, Volume 7, Number 6, Page e38380
[2]
Javier Márquez, José A. Campos-Sandoval, Ana Peñalver, José M. Matés, Juan A. Segura, Eduardo Blanco, Francisco J. Alonso, and Fernando Rodríguez de Fonseca
Neurochemical Research, 2017, Volume 42, Number 3, Page 846
[3]
José A. Campos-Sandoval, Mercedes Martín-Rufián, Carolina Cardona, Carolina Lobo, Ana Peñalver, and Javier Márquez
Neurochemistry International, 2015, Volume 88, Page 1
[4]
Carolina Cardona, Elisabeth Sánchez-Mejías, José C. Dávila, Mercedes Martín-Rufián, José A. Campos-Sandoval, Javier Vitorica, Francisco J. Alonso, José M. Matés, Juan A. Segura, Michael D. Norenberg, Kakulavarapu V. Rama Rao, Arumugan R. Jayakumar, Antonia Gutiérrez, and Javier Márquez
Glia, 2015, Volume 63, Number 3, Page 365
[5]
Javier Márquez, Carolina Cardona, José A. Campos-Sandoval, Ana Peñalver, Marta Tosina, José M. Matés, and Mercedes Martín-Rufián
Metabolic Brain Disease, 2013, Volume 28, Number 2, Page 133

Comments (0)

Please log in or register to comment.
Log in