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Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico


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CiteScore 2018: 3.35

SCImago Journal Rank (SJR) 2018: 1.475
Source Normalized Impact per Paper (SNIP) 2018: 0.825

ICV 2018: 124.31

Open Access
Online
ISSN
1868-503X
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Volume 1, Issue 1

Issues

Recent progress in the field of neoglycoconjugate chemistry

Carmen Jiménez-Castells
  • Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park, Dr. Aiguader 88, 08003 Barcelona, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sira Defaus
  • Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park, Dr. Aiguader 88, 08003 Barcelona, Spain
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  • De Gruyter OnlineGoogle Scholar
/ David Andreu
  • Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park, Dr. Aiguader 88, 08003 Barcelona, Spain
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  • De Gruyter OnlineGoogle Scholar
/ Ricardo Gutiérrez-Gallego
  • Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park, Dr. Aiguader 88, 08003 Barcelona, Spain
  • Pharmacology Research Unit, Bio-analysis group, Neuropsychopharmacology program, Municipal Institute of Medical Research IMIM-Hospital del Mar, Barcelona Biomedical Research Park, Dr. Aiguader 88, 08003 Barcelona, Spain
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-04-06 | DOI: https://doi.org/10.1515/bmc.2010.007

Abstract

Glycosylation is probably the most complex secondary gene event that affects the vast majority of proteins in nature resulting in the occurrence of a heterogeneous mixture of glycoforms for a single protein. Many functions are exerted by single monosaccharides, well-defined oligosaccharides, or larger glycans present in these glycoproteins. To unravel these functions it is of the utmost importance to prepare well-defined single glycans conjugated to the underlying aglycon. In this review, the most recent developments are described to address the preparation of carbohydrate-amino acid (glyco-conjugates). Naturally occurring N- and O-linked glycosylation are described and the preparation of non-natural sugar-amino acid linkages are also included.

Keywords: biomolecular interactions; glycosylation; neoglycopeptides; synthesis

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Published Online: 2010-04-06

Published in Print: 2010-05-01


Citation Information: BioMolecular Concepts, Volume 1, Issue 1, Pages 85–96, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc.2010.007.

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