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Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico

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CiteScore 2017: 2.50

SCImago Journal Rank (SJR) 2017: 0.861
Source Normalized Impact per Paper (SNIP) 2017: 0.722

ICV 2017: 131.30

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Volume 1, Issue 2


Seven essential questions on G-quadruplexes

Sebastian L.B. König
  • Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK
  • Ecole Supérieure de Biotechnologie de Strasbourg (ESBS) Boulevard Sébastien Brandt, 67412 Illkirch-Graffenstaden, France
  • Other articles by this author:
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/ Amanda C. Evans / Julian L. Huppert
Published Online: 2010-06-22 | DOI: https://doi.org/10.1515/bmc.2010.011


The helical duplex architecture of DNA was discovered by Francis Crick and James Watson in 1951 and is well known and understood. However, nucleic acids can also adopt alternative structural conformations that are less familiar, although no less biologically relevant, such as the G-quadruplex. G-quadruplexes continue to be the subject of a rapidly expanding area of research, owing to their significant potential as therapeutic targets and their unique biophysical properties. This review begins by focusing on G-quadruplex structure, elucidating the intermolecular and intramolecular interactions underlying its formation and highlighting several substructural variants. A variety of methods used to characterize these structures are also outlined. The current state of G-quadruplex research is then addressed by proffering seven pertinent questions for discussion. This review concludes with an overview of possible directions for future research trajectories in this exciting and relevant field.

Keywords: DNA; G-quadruplexes; promoter; proto-oncogenes; RNA; telomeres; transcription

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Published Online: 2010-06-22

Published in Print: 2010-08-01

Citation Information: BioMolecular Concepts, Volume 1, Issue 2, Pages 197–213, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc.2010.011.

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