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Biomolecular Concepts

Editor-in-Chief: AVILA, Jesus

1 Issue per year

covered by Web of Science (BIOSIS Previews)


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CiteScore 2016: 2.39

SCImago Journal Rank (SJR) 2016: 0.753
Source Normalized Impact per Paper (SNIP) 2016: 0.567

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Online
ISSN
1868-503X
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Volume 1, Issue 3-4

Issues

RNA duplexes in transcriptional regulation

Sanjay Swaminathan
  • Immunovirology Laboratory, St. Vincent's Centre for Applied Medical Research, Darlinghurst 2010, NSW, Australia
  • National Centre in HIV Epidemiology and Clinical Research, UNSW, Darlinghurst 2010, NSW, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Chantelle L. Hood
  • Immunovirology Laboratory, St. Vincent's Centre for Applied Medical Research, Darlinghurst 2010, NSW, Australia
  • National Centre in HIV Epidemiology and Clinical Research, UNSW, Darlinghurst 2010, NSW, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kazuo Suzuki
  • Immunovirology Laboratory, St. Vincent's Centre for Applied Medical Research, Darlinghurst 2010, NSW, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Anthony D. Kelleher
  • Immunovirology Laboratory, St. Vincent's Centre for Applied Medical Research, Darlinghurst 2010, NSW, Australia
  • National Centre in HIV Epidemiology and Clinical Research, UNSW, Darlinghurst 2010, NSW, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-09-08 | DOI: https://doi.org/10.1515/bmc.2010.021

Abstract

Transcriptional regulation by small RNA molecules, including small interfering RNA and microRNA, has emerged as an important gene expression modulator. The regulatory pathways controlling gene expression, post-transcriptional gene silencing and transcriptional gene silencing (TGS) have been demonstrated in yeast, plants and more recently in human cells. In this review, we discuss the currents models of transcriptional regulation and the main components of the RNA-induced silencing complex and RNA-induced transcriptional silencing complex machinery, as well as confounding off-target effects and gene activation. We also discuss RNA-mediated TGS within the NF-κB motif of the human immunodeficiency virus type 1 5′ long tandem repeat promoter region and the associated epigenetic modifications. Finally, we outline the current RNA interference (RNAi) delivery methods and describe the current status of human trials investigating potential RNAi therapeutics for several human diseases.

Keywords: gene expression regulation; gene silencing; microRNAs; RNA interference; small interfering RNA

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Published Online: 2010-09-08

Published in Print: 2010-10-01


Citation Information: BioMolecular Concepts, Volume 1, Issue 3-4, Pages 285–296, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc.2010.021.

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