Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biomolecular Concepts

Editor-in-Chief: Jollès, Pierre / Mansuy, Isabelle

Editorial Board Member: Avila, Jesus / Bonetto, Valentina / Cera, Enrico / Jorgensen, Erik / Jörnvall, Hans / Lagasse, Eric / Norman, Robert / Pinna, Lorenzo / Raghavan, K. Vijay / Venetianer, Pal / Wahli, Walter

6 Issues per year

CiteScore 2016: 2.39

SCImago Journal Rank (SJR) 2016: 0.753
Source Normalized Impact per Paper (SNIP) 2016: 0.567

See all formats and pricing
More options …

MAPKs in development: insights from Dictyostelium signaling pathways

Jeffrey A. Hadwiger / Hoai-Nghia Nguyen
  • Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078-3020, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-02-16 | DOI: https://doi.org/10.1515/bmc.2011.004


Mitogen activated protein kinases (MAPKs) play important roles in the development of eukaryotic organisms through the regulation of signal transduction pathways stimulated by external signals. MAPK signaling pathways have been associated with the regulation of cell growth, differentiation, and chemotaxis, indicating that MAPKs contribute to a diverse set of developmental processes. In most eukaryotes, the diversity of external signals is likely to far exceed the diversity of MAPKs, suggesting that multiple signaling pathways might share MAPKs. Do different signaling pathways converge before MAPK function or can MAPKs maintain signaling specificity through interactions with specific proteins? The genetic and biochemical analysis of MAPK pathways in simple eukaryotes such as Dictyostelium offers opportunities to investigate functional specificity of MAPKs in G-protein-mediated signal transduction pathways. This review considers the regulation and specificity of MAPK function in pathways that control Dictyostelium growth and development.

Keywords: Dictyostelium; extracellular signal regulated kinase 1 (ERK1); ERK2; G protein; mitogen activated protein kinase (MAPK)

About the article

Published Online: 2011-02-16

Published in Print: 2011-04-01

Citation Information: BioMolecular Concepts, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc.2011.004.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Patrick M. Suess, Jacob Watson, Wensheng Chen, and Richard H. Gomer
Journal of Cell Science, 2017, Volume 130, Number 14, Page 2394
Swati Singh, Anoop Chaturvedi, and Ashutosh Mani
Interdisciplinary Sciences: Computational Life Sciences, 2015, Volume 7, Number 4, Page 357
David J. Schwebs and Jeffrey A. Hadwiger
Cellular Signalling, 2015, Volume 27, Number 1, Page 147
Jiaying Wu, Zongfu Pan, Meiyuan Cheng, Yuanyuan Shen, Hao Yu, Qiongyue Wang, and Yijia Lou
Neurochemistry International, 2013, Volume 62, Number 1, Page 92
Zhi-gang WANG, Wei-ze ZHANG, Ling MA, Yong-qing CHEN, Tao LI, Fang-ju SU, and Pei-hong LI
Academic Journal of Second Military Medical University, 2012, Volume 32, Number 3, Page 259

Comments (0)

Please log in or register to comment.
Log in