Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico


Covered by Web of Science (BIOSIS Previews)

PubMed Indexed

CiteScore 2018: 3.35

SCImago Journal Rank (SJR) 2018: 1.475
Source Normalized Impact per Paper (SNIP) 2018: 0.825

ICV 2017: 131.30

Open Access
Online
ISSN
1868-503X
See all formats and pricing
More options …
Volume 2, Issue 4

Issues

Retinoblastoma family of proteins and chromatin epigenetics: a repetitive story in a few LINEs

Diego E. Montoya-Durango
  • Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kenneth S. Ramos
  • Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-08-05 | DOI: https://doi.org/10.1515/bmc.2011.027

Abstract

The retinoblastoma (RB) protein family in mammals is composed of three members: pRB (or RB1), p107, and p130. Although these proteins do not directly bind DNA, they associate with the E2F family of transcription factors which function as DNA sequence-specific transcription factors. RB proteins alter gene transcription via direct interference with E2F functions, as well as recruitment of transcriptional repressors and corepressors that silence gene expression through DNA and histone modifications. E2F/RB complexes shape the chromatin landscape through recruitment to CpG-rich regions in the genome, thus making E2F/RB complexes function as local and global regulators of gene expression and chromatin dynamics. Recruitment of E2F/pRB to the long interspersed nuclear element (LINE1) promoter enhances the role that RB proteins play in genome-wide regulation of heterochromatin. LINE1 elements are dispersed throughout the genome and therefore recruitment of RB to the LINE1 promoter suggests that LINE1 could serve as the scaffold on which RB builds up heterochromatic regions that silence and shape large stretches of chromatin. We suggest that mutations in RB function might lead to global rearrangement of heterochromatic domains with concomitant retrotransposon reactivation and increased genomic instability. These novel roles for RB proteins open the epigenetic-based way for new pharmacological treatments of RB-associated diseases, namely inhibitors of histone and DNA methylation, as well as histone deacetylase inhibitors.

Keywords: chromatin; E2F; long interspersed nuclear element (LINE1 or L1); nucleosome; retinoblastoma protein family

About the article

Received: 2011-04-08

Accepted: 2011-05-31

Published Online: 2011-08-05

Published in Print: 2011-08-01


Citation Information: BioMolecular Concepts, Volume 2, Issue 4, Pages 233–245, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc.2011.027.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Wen-Jian Meng, Surajit Pathak, Zhen-Yu Ding, Hong Zhang, Gunnar Adell, Birgitta Holmlund, Yuan Li, Zong-Guang Zhou, and Xiao-Feng Sun
Cancer Biology & Therapy, 2015, Volume 16, Number 12, Page 1738

Comments (0)

Please log in or register to comment.
Log in