Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biomolecular Concepts

Editor-in-Chief: AVILA, Jesus

1 Issue per year


Covered by Web of Science (BIOSIS Previews)

PubMed Indexed

CiteScore 2017: 2.50

SCImago Journal Rank (SJR) 2017: 0.861
Source Normalized Impact per Paper (SNIP) 2017: 0.722

ICV 2017: 131.30

Online
ISSN
1868-503X
See all formats and pricing

Access brought to you by:

provisional account

Open Access
More options …
Volume 3, Issue 1

Issues

Are synonymous codons indeed synonymous?

Pál Venetianer
Published Online: 2011-11-30 | DOI: https://doi.org/10.1515/bmc.2011.050

Abstract

It has long been known that the distribution and frequency of occurence of synonymous codons can vary greatly among different species, and that the abundance of isoaccepting tRNA species could also be very different. The interaction of these two factors may influence the rate and efficiency of protein synthesis and therefore synonymous mutations might influence the fitness of the organism and cannot be treated generally as ‘neutral’ in an evolutionary sense. These general effects of synonymous mutations, and their possible role in evolution, have been discussed in several recent papers. This review, however, will only deal with the influence of synonymous codon replacements on the expression of individual genes. It will describe the possible mechanisms of such effects and will present examples demonstrating the existence and effects of each of these mechanisms.

Keywords: isoaccepting tRNA; miRNA; mRNA half-life; mRNA secondary structure; synonymous codon; translation kinetics

About the article

Received: 2011-07-14

Accepted: 2011-10-25

Published Online: 2011-11-30

Published in Print: 2012-02-01


Citation Information: BioMolecular Concepts, Volume 3, Issue 1, Pages 21–28, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc.2011.050.

Export Citation

©2012 by Walter de Gruyter Berlin Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Nancy M. Cladel, Lynn R. Budgeon, Jiafen Hu, Karla K. Balogh, and Neil D. Christensen
Virology, 2013, Volume 438, Number 2, Page 70

Comments (0)

Please log in or register to comment.
Log in