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Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico


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CiteScore 2018: 3.35

SCImago Journal Rank (SJR) 2018: 1.475
Source Normalized Impact per Paper (SNIP) 2018: 0.825

ICV 2017: 131.30

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Online
ISSN
1868-503X
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Volume 3, Issue 2

Issues

Keratin function and regulation in tissue homeostasis and pathogenesis

Wera Roth
  • Division of Cell and Developmental Biology, Translational Centre for Regenerative Medicine (TRM) and Biology, University of Leipzig, D-04103 Leipzig, Germany
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/ Mechthild Hatzfeld
  • Institut für Molekulare Medizin, Sektion Pathobiochemie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Hollystra\xdfe 1, 06097 Halle, Germany
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/ Maik Friedrich
  • Division of Cell and Developmental Biology, Translational Centre for Regenerative Medicine (TRM) and Biology, University of Leipzig, D-04103 Leipzig, Germany
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/ Sören Thiering
  • Division of Cell and Developmental Biology, Translational Centre for Regenerative Medicine (TRM) and Biology, University of Leipzig, D-04103 Leipzig, Germany
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/ Thomas M. Magin
  • Division of Cell and Developmental Biology, Translational Centre for Regenerative Medicine (TRM) and Biology, University of Leipzig, D-04103 Leipzig, Germany
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Published Online: 2012-02-14 | DOI: https://doi.org/10.1515/bmc.2011.060

Abstract

Epithelial tissues act as hubs in metabolism and communication and protect the organism against dehydration, infections, pharmacological and physical stress. Keratin intermediate filament proteins are well established as major cytoskeletal players in maintaining epithelial integrity. More recently, an involvement of keratins in growth control and organelle functions has emerged. Disruption of the keratin cytoskeleton by mutations or its reorganization following posttranslational modifications can render epithelia susceptible to tissue damage and various stresses, while loss of keratin expression is a hallmark of epithelial-mesenchymal transition (EMT). To understand the molecular mechanisms by which keratins perform their functions remains a formidable challenge. Based on selected examples, we will discuss how cell-specific expression of keratin isotypes affects cytoarchitecture and cell behavior. Further, we ask how posttranslational modifications alter keratin organization and interactions during signaling. Next, we discuss pathomechanisms of epidermal keratin disorders in the light of novel data. Finally, we raise open questions and point out future directives.

Keywords: cell growth; keratins; posttranslational modification; protein biosynthesis; stress response

About the article

Corresponding author


Received: 2011-09-13

Accepted: 2011-12-19

Published Online: 2012-02-14

Published in Print: 2012-04-01


Citation Information: Biomolecular Concepts, Volume 3, Issue 2, Pages 161–173, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc.2011.060.

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