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Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico

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CiteScore 2018: 3.35

SCImago Journal Rank (SJR) 2018: 1.475
Source Normalized Impact per Paper (SNIP) 2018: 0.825

ICV 2017: 131.30

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Volume 3, Issue 4


Role of extracellular matrix in regulating embryonic epithelial-mesenchymal transition

Francesca Zito
  • Corresponding author
  • Istituto di Biomedicina e Immunologia Molecolare ‘Alberto Monroy’, Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, I-90146 Palermo, Italy
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Published Online: 2012-05-01 | DOI: https://doi.org/10.1515/bmc-2011-0065


Embryogenesis and morphogenesis are characterized by complex cell rearrangements and movements which require appropriate interactions of cells with the surrounding extracellular matrix (ECM) by means of specific membrane receptors. Interest in the identification and purification of ECM components, as well as in conducting functional studies of them, including their ligands and other molecules involved in cell-matrix adhesion, has intensified in recent years, increasing our knowledge of developmental machinery. Cellular movements play an important role during the epithelial-mesenchymal transition (EMT) events, which are key processes in normal embryogenesis as well as in pathological conditions, such as fibrotic diseases and cancer. Thus, to more fully understand mechanisms underlying the EMT process, and for better knowledge of the embryonic defects related to this process, it would be useful to study the substrates on which EMT cells move during embryo development. This review focuses on a few different embryonic systems, taking into account the cell migration that occurs during EMT and highlighting, in particular, studies describing the direct involvement of ECM molecules.

Keywords: basement membrane; cell migration; heart development; neural crest; sea urchin embryo

About the article

Received: 2011-12-07

Accepted: 2012-03-23

Published Online: 2012-05-01

Published in Print: 2012-08-01

Citation Information: BioMolecular Concepts, Volume 3, Issue 4, Pages 333–344, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc-2011-0065.

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©2012 by Walter de Gruyter Berlin Boston.Get Permission

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