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Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico


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CiteScore 2018: 3.35

SCImago Journal Rank (SJR) 2018: 1.475
Source Normalized Impact per Paper (SNIP) 2018: 0.825

ICV 2017: 131.30

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Online
ISSN
1868-503X
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Volume 3, Issue 4

Issues

Scavenger receptors: a key player in cardiovascular diseases

Mohammad Z. Ashraf
  • Corresponding author
  • Genomics Group, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, India
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  • Other articles by this author:
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/ Anita Sahu
  • Genomics Group, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-05-04 | DOI: https://doi.org/10.1515/bmc-2012-0003

Abstract

The scavenger receptor (SR) super family consists of integral membrane glycoproteins that are involved in recognition of polyanionic structures of either endogenous (e.g., oxidized low-density lipoprotein) or exogenous (e.g., bacterial lipopolysaccharides) origin. SRs are structurally diverse and can be classified into seven different classes (A–G) based on the multidomain structure of the individual members. SRs are present on various types of tissues, such as vascular, adipose, and steroidogenic tissues. In addition to modified lipoprotein uptake, these proteins are also known to regulate apoptotic cell clearance, initiate signal transduction, and serve as pattern recognition receptors for pathogens. Different SRs are involved in many physiological and pathological processes; more importantly, the function of SRs is highly implicated in the initiation and progression of atherosclerotic plaque. Targeting the SR gene products that mediate the response to and uptake of modified lipids holds great promise in the prevention of cardiovascular diseases. Inhibition of SR expression using a combined gene therapy and RNA interference strategy also appears to be an option for long-term therapy. The present review focuses on the involvement of SRs in atherosclerosis, thrombosis, and other cardiovascular diseases. Moreover, the role of SRs is not restricted to vascular lesions; it is also implicated in a number of different cellular functions.

Keywords: atherosclerosis; lipoproteins; oxidized phospholipids; scavenger receptors; thrombosis

About the article

Mohammad Z. Ashraf

Dr. M. Zahid Ashraf is currently leading the Genomics Group at Defense Institute of Physiology and Allied Sciences (DIPAS), Delhi, India. He has received his Post Doctoral Training from Lerner Research Institute, Cleveland Clinic, Cleveland, USA. During his tenure at Cleveland he has worked in the area of Cardiovascular Biology, especially the involvement of Scavenger Receptors in Atherothrombotic Disorders. He has made a signifi cant contribution in the area of atherosclerosis by exploring the role of lipoproteins and oxidized phospholipids in foam cell formation. Dr. Ashraf, to his credit, has published around 20 papers in International Journals including Blood, Circulation Research, MCB, JBC etc. He has been a recipient of prestigious Cleveland Clinic Innovation Award in 2008.

Anita Sahu

Anita Sahu is a talented graduate student under the mentorship of Mohammad Z Ashraf at Defense Institute of Physiology and Allied Sciences (DIPAS), Delhi, India. Her ongoing research deals with under standing the pathophysiology of thro mbotic disorders. She is actively involved in a wide spectrum of research ranging from gene expression analysis, epigenetic modifi cations of nucleic acid to gene regulation by microRNA studies.


Corresponding author


Received: 2012-02-07

Accepted: 2012-04-02

Published Online: 2012-05-04

Published in Print: 2012-08-01


Citation Information: BioMolecular Concepts, Volume 3, Issue 4, Pages 371–380, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc-2012-0003.

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