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Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico


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CiteScore 2018: 3.35

SCImago Journal Rank (SJR) 2018: 1.475
Source Normalized Impact per Paper (SNIP) 2018: 0.825

ICV 2017: 131.30

Open Access
Online
ISSN
1868-503X
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Volume 3, Issue 4

Issues

Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing

Jirina Prochazkova
  • Corresponding author
  • Department of Animal Physiology and Immunology, Faculty of Science, Masaryk University, Kotlarska 2, CZ-611 37 Brno, Czech Republic
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Martina Lanova
  • Department of Animal Physiology and Immunology, Faculty of Science, Masaryk University, Kotlarska 2, CZ-611 37 Brno, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jiri Pachernik
  • Department of Animal Physiology and Immunology, Faculty of Science, Masaryk University, Kotlarska 2, CZ-611 37 Brno, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-05-11 | DOI: https://doi.org/10.1515/bmc-2012-0006

Abstract

Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP. This study is not only focused on function, substrates, and localization of these popular proteins but also on other ABC C family members such as ABC C2–6/MRP2-6 and ABC C7/CFTR. Current research is mainly oriented on the cancer-promoting role of these proteins, but important lessons could also be learned from the physiological roles of these proteins or from polymorphisms affecting their function. Thorough knowledge of structure and detailed mechanism of efflux can aid in the discovery of new chemotherapy targets in the future. Although the best way on how to deal with MDR would be to prevent its development, we describe some new promising strategies on how to conquer both inherited and induced MDRs.

Keywords: ABC transporters; barrier; multidrug resistance; polymorphism; substrate

About the article

Corresponding author


Received: 2012-02-22

Accepted: 2012-04-11

Published Online: 2012-05-11

Published in Print: 2012-08-01


Citation Information: BioMolecular Concepts, Volume 3, Issue 4, Pages 319–331, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc-2012-0006.

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