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Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico


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CiteScore 2018: 3.35

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1868-503X
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Volume 3, Issue 6

Issues

Cyclin A2: a genuine cell cycle regulator?

Nawal Bendris
  • Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
  • Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, 1919 route de Mende, F-34293 Montpellier, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France
  • Université Montpellier 1, 5 Boulevard Henri IV, F-34967 Montpellier, France
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/ Abdelhalim Loukil
  • Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, 1919 route de Mende, F-34293 Montpellier, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France
  • Université Montpellier 1, 5 Boulevard Henri IV, F-34967 Montpellier, France
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/ Caroline Cheung
  • Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, 1919 route de Mende, F-34293 Montpellier, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France
  • Université Montpellier 1, 5 Boulevard Henri IV, F-34967 Montpellier, France
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/ Nikola Arsic
  • Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, 1919 route de Mende, F-34293 Montpellier, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France
  • Université Montpellier 1, 5 Boulevard Henri IV, F-34967 Montpellier, France
  • Centre de Recherche en Biochimie Macromoléculaire, Centre National de la Recherche Scientifique, 1919 route de Mende, F-34293 Montpellier, France
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/ Cosette Rebouissou
  • Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, 1919 route de Mende, F-34293 Montpellier, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France
  • Université Montpellier 1, 5 Boulevard Henri IV, F-34967 Montpellier, France
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/ Robert Hipskind
  • Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, 1919 route de Mende, F-34293 Montpellier, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France
  • Université Montpellier 1, 5 Boulevard Henri IV, F-34967 Montpellier, France
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/ Marion Peter
  • Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, 1919 route de Mende, F-34293 Montpellier, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France
  • Université Montpellier 1, 5 Boulevard Henri IV, F-34967 Montpellier, France
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/ Bénédicte Lemmers
  • Corresponding author
  • Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, 1919 route de Mende, F-34293 Montpellier, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France
  • Université Montpellier 1, 5 Boulevard Henri IV, F-34967 Montpellier, France
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/ Jean Marie Blanchard
  • Corresponding author
  • Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, 1919 route de Mende, F-34293 Montpellier, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France
  • Université Montpellier 1, 5 Boulevard Henri IV, F-34967 Montpellier, France
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Published Online: 2012-08-28 | DOI: https://doi.org/10.1515/bmc-2012-0027

Abstract

Cyclin A2 belongs to the core cell cycle regulators and participates in the control of both S phase and mitosis. However, several observations suggest that it is also endowed with other functions, and our recent data shed light on its involvement in cytoskeleton dynamic and cell motility. From the transcription of its gene to its posttranslational modifications, cyclin A2 regulation reveals the complexity of the regulatory network shaping cell cycle progression. We summarize our current knowledge on this cell cycle regulator and discuss recent findings raising the possibility that cyclin A2 might play a much broader role in epithelial tissues homeostasis.

Keywords: cytoskeleton; degradation; invasion; mitosis; Rho GTPases; S phase; transcription

About the article

Corresponding authors


Received: 2012-06-26

Accepted: 2012-07-26

Published Online: 2012-08-28

Published in Print: 2012-12-01


Citation Information: BioMolecular Concepts, Volume 3, Issue 6, Pages 535–543, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc-2012-0027.

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