Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico


Covered by Web of Science (BIOSIS Previews)

PubMed Indexed

CiteScore 2017: 2.50

SCImago Journal Rank (SJR) 2017: 0.861
Source Normalized Impact per Paper (SNIP) 2017: 0.722

ICV 2017: 131.30

Open Access
Online
ISSN
1868-503X
See all formats and pricing
More options …
Volume 4, Issue 1

Issues

Elastin peptides in aging and pathological conditions

Stéphanie Baud
  • Laboratoire Signalisation et Récepteurs Matriciels, UMR CNRS 6237, Université de Reims Champagne Ardenne, Faculté des Sciences, Moulin de la Housse, BP 1039, F-51687 Reims cedex 2, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Laurent Duca
  • Laboratoire Signalisation et Récepteurs Matriciels, UMR CNRS 6237, Université de Reims Champagne Ardenne, Faculté des Sciences, Moulin de la Housse, BP 1039, F-51687 Reims cedex 2, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Brigida Bochicchio
  • Department of Chemistry ‘A.M. Tamburro’, Università degli Studi della Basilicata, Via Ateneo Lucano, 10, I-85100 Potenza, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Bertrand Brassart
  • Laboratoire Signalisation et Récepteurs Matriciels, UMR CNRS 6237, Université de Reims Champagne Ardenne, Faculté des Sciences, Moulin de la Housse, BP 1039, F-51687 Reims cedex 2, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nicolas Belloy
  • Laboratoire Signalisation et Récepteurs Matriciels, UMR CNRS 6237, Université de Reims Champagne Ardenne, Faculté des Sciences, Moulin de la Housse, BP 1039, F-51687 Reims cedex 2, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Antonietta Pepe
  • Department of Chemistry ‘A.M. Tamburro’, Università degli Studi della Basilicata, Via Ateneo Lucano, 10, I-85100 Potenza, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Manuel Dauchez
  • Laboratoire Signalisation et Récepteurs Matriciels, UMR CNRS 6237, Université de Reims Champagne Ardenne, Faculté des Sciences, Moulin de la Housse, BP 1039, F-51687 Reims cedex 2, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Laurent Martiny
  • Laboratoire Signalisation et Récepteurs Matriciels, UMR CNRS 6237, Université de Reims Champagne Ardenne, Faculté des Sciences, Moulin de la Housse, BP 1039, F-51687 Reims cedex 2, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Laurent Debelle
  • Corresponding author
  • Laboratoire Signalisation et Récepteurs Matriciels, UMR CNRS 6237, Université de Reims Champagne Ardenne, Faculté des Sciences, Moulin de la Housse, BP 1039, F-51687 Reims cedex 2, France
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-09-22 | DOI: https://doi.org/10.1515/bmc-2011-0062

Abstract

Elastin is the protein responsible for the resilience of vertebrate tissue. It is an extremely stable protein deposited during the early stages of life and experiencing almost no renewal. As a consequence, it can be considered that each individual has an elastin capital for life. Despite its extreme stability, elastin can be degraded by several enzymes termed elastases. Elastases are among the most aggressive proteases, and their presence is increased with age. As a consequence, elastin fragmentation resulting in the generation of elastin peptides is one of the hallmarks of aging. This review will examine their nature and further expose our current understanding of the role played by these peptides in aging and their contribution to tissue homeostasis and several pathologies.

Keywords: aging; amyloid; elastin; elastin peptides; receptors

About the article

Corresponding author: Laurent Debelle, Laboratoire Signalisation et Récepteurs Matriciels, UMR CNRS 6237, Université de Reims Champagne Ardenne, Faculté des Sciences, Moulin de la Housse, BP 1039, F-51687 Reims cedex 2, France


Received: 2011-11-21

Accepted: 2012-08-29

Published Online: 2012-09-22

Published in Print: 2013-02-01


Citation Information: BioMolecular Concepts, Volume 4, Issue 1, Pages 65–76, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc-2011-0062.

Export Citation

©2013 by Walter de Gruyter Berlin Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Jeppe Thorlacius-Ussing, Stephanie Nina Kehlet, Sarah Rank Rønnow, Morten Asser Karsdal, and Nicholas Willumsen
Journal of Cancer Research and Clinical Oncology, 2018
[2]
Stéphanie Salesse, Ludivine Odoul, Lise Chazée, Christian Garbar, Laurent Duca, Laurent Martiny, Rachid Mahmoudi, and Laurent Debelle
FEBS Open Bio, 2018
[3]
Angela C. Mora Huertas, Christian E.H. Schmelzer, Chiara Luise, Wolfgang Sippl, Markus Pietzsch, Wolfgang Hoehenwarter, and Andrea Heinz
Biochimie, 2018, Volume 146, Page 73
[4]
Renata Ochocka, Anna Hering, Justyna Stefanowicz–Hajduk, Krzysztof Cal, Helena Barańska, and Hélder A. Santos
PLOS ONE, 2017, Volume 12, Number 7, Page e0181542
[5]
Sylvie Ricard-Blum and Sylvain D. Vallet
Biochimie, 2016, Volume 122, Page 300
[6]
Brigida Bochicchio, Antonietta Pepe, Maria Crudele, Nicolas Belloy, Stephanie Baud, and Manuel Dauchez
Soft Matter, 2015, Volume 11, Number 17, Page 3385
[7]
L. Robert and J. Labat-Robert
Pathologie Biologie, 2014, Volume 62, Number 6, Page 337
[8]
Antonietta Pepe, Maria Antonietta Crudele, and Brigida Bochicchio
New Journal of Chemistry, 2013, Volume 37, Number 5, Page 1326

Comments (0)

Please log in or register to comment.
Log in