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Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico

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Volume 4, Issue 1


Tropomodulins and tropomyosins – organizers of cellular microcompartments

Thomas Fath
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  • School of Medical Sciences, University of New South Wales, Wallace Wurth Building (C27), G18, Sydney 2052, NSW, Australia
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Published Online: 2012-11-30 | DOI: https://doi.org/10.1515/bmc-2012-0037


Eukaryotic cells show a remarkable compartmentalization into compartments such as the cell nucleus, the Golgi apparatus, the endoplasmic reticulum, and endosomes. However, organelle structures are not the only means by which specialized compartments are formed. Recent research shows a critical role for diverse actin filament populations in defining functional compartments, here referred to as microcompartments, in a wide range of cells. These microcompartments are involved in regulating fundamental cellular functions including cell motility, plasma membrane organization, and cellular morphogenesis. In this overview, the importance of two multigene families of actin-associated proteins, tropomodulins and tropomyosins, their interactions with each other, and a large number of other proteins will be discussed in the context of generating specialized actin-based microcompartments.

Keywords: actin; cellular compartments; tropomodulin; tropomyosin

About the article

Thomas Fath

Thomas Fath is a senior lecturer at the School of Medical Sciences of the University of New South Wales in Sydney, NSW, Australia. He received a PhD in Biology from the University of Heidelberg and built his expertise on the regulation of the actin cytoskeleton by Tmod and Tm in the nervous system during postdoctoral training in the laboratories of Professor Velia Fowler at the Scripps Research Institute in La Jolla, CA, USA, and Professor Peter Gunning at the Children’s Hospital at Westmead, Sydney, NSW, Australia. His research focuses on understanding the role of the cytoskeleton in cellular morphogenesis and function, with a particular interest in the actin cytoskeleton in the nervous system.

Corresponding author: Thomas Fath, School of Medical Sciences, University of New South Wales, Wallace Wurth Building (C27), G18, Sydney 2052, NSW, Australia

Received: 2012-09-05

Accepted: 2012-10-30

Published Online: 2012-11-30

Published in Print: 2013-02-01

Citation Information: BioMolecular Concepts, Volume 4, Issue 1, Pages 89–101, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc-2012-0037.

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