Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico


Covered by Web of Science (BIOSIS Previews)

PubMed Indexed

CiteScore 2017: 2.50

SCImago Journal Rank (SJR) 2017: 0.861
Source Normalized Impact per Paper (SNIP) 2017: 0.722

ICV 2017: 131.30

Open Access
Online
ISSN
1868-503X
See all formats and pricing
More options …
Volume 4, Issue 1

Issues

RNAi and retroviruses: are they in RISC?

Thierry Vasselon
  • Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, 1919 route de Mende, F-34293 Montpellier cedex 5, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier cedex 5, France
  • Université Montpellier 1, 5 Bd Henry IV, F-34967 Montpellier cedex 2, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Manuella Bouttier
  • Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, 1919 route de Mende, F-34293 Montpellier cedex 5, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier cedex 5, France
  • Université Montpellier 1, 5 Bd Henry IV, F-34967 Montpellier cedex 2, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Anne Saumet
  • Institut de Recherche en Cancérologie de Montpellier INSERM U896, Université Montpellier 1, Centre Régional de Lutte Contre le Cancer Val d’Aurelle Paul Lamarque, F-34298 Montpellier, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Charles-Henri Lecellier
  • Corresponding author
  • Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, 1919 route de Mende, F-34293 Montpellier cedex 5, France
  • Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier cedex 5, France
  • Université Montpellier 1, 5 Bd Henry IV, F-34967 Montpellier cedex 2, France
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-01-05 | DOI: https://doi.org/10.1515/bmc-2012-0041

Abstract

RNA interference (RNAi) is a potent cellular system against viruses in various organisms. Although common traits are observed in plants, insects, and nematodes, the situation observed in mammals appears more complex. In mammalian somatic cells, RNAi is implicated in endonucleolytic cleavage mediated by artificially delivered small interfering RNAs (siRNAs) as well as in translation repression mediated by microRNAs (miRNAs). Because siRNAs and miRNAs recognize viral mRNAs, RNAi inherently limits virus production and participates in antiviral defense. However, several observations made in the cases of hepatitis C virus and retroviruses (including the human immunodeficiency virus and the primate foamy virus) bring evidence that this relationship is much more complex and that certain components of the RNAi effector complex [called the RNA-induced silencing complex (RISC)], such as AGO2, are also required for viral replication. Here, we summarize recent discoveries that have revealed this dual implication in virus biology. We further discuss their potential implications for the functions of RNAi-related proteins, with special emphasis on retrotransposition and genome stability.

Keywords: Argonaute; AGO2; foamy virus; hepatitis C virus (HCV); human immunodeficiency virus type 1 (HIV-1); microRNAs; retrovirus; virus

About the article

Thierry Vasselon

Thierry Vasselon holds a PhD degree in Microbiology from the University of Paris VI, Paris, France. His work has focussed on the mechanisms of pathogen recognition by the innate immune response and on early responses to pathogens. His interest in microRNAs modulated by bacteria and viruses started in 2008, when he started working in collaboration and then directly with C.-H. Lecellier at the Institut de Génétique Moléculaire de Montpellier, Montpellier, France.

Manuella Bouttier

Manuella Bouttier holds a PhD degree in Molecular Biology from the University of Montpellier, Montpellier, France. During her thesis, she worked under the supervision of C.-H. Lecellier and notably showed that the retroviral GAG proteins recruit AGO2 on viral RNAs without affecting RNA accumulation and translation. Since 2011, she has been working on the effects of vitamin D on Mycobacterium tuberculosis at the McGill University. She is particularly interested in innate immune responses and transcriptomic modulations in host macrophages.

Anne Saumet

Anne Saumet holds a PhD degree in Cell Biology from the University of Paris VII, Paris, France. Her interest in microRNAs and viruses started in 2005, when she joined the Institute of Plant Molecular Biology in Strasbourg, France. There she also worked on the contribution of microRNAs in cancers. Since 2008, she has been in charge of a project aimed at characterizing genetic and epigenetic events associated with the early steps of breast cancer in the Cancer Research Institute of Montpellier, Montpellier, France.

Charles-Henri Lecellier

Charles-Henri Lecellier holds a PhD degree in Virology from the University of Paris VII, Paris, France. Results obtained during his thesis led him to the Institute of Plant Molecular Biology to study antiviral RNAi in mammals, and there he implicated the microRNA pathway in retroviral replication. Since 2007, he has been working at the Institut de Génétique Moléculaire de Montpellier, Montpellier, France, with particular interest on the complex interplay between the microRNA machinery and viral replication.


Corresponding author: Charles-Henri Lecellier, Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, 1919 route de Mende, F-34293 Montpellier cedex 5, France


Received: 2012-10-04

Accepted: 2012-11-20

Published Online: 2013-01-05

Published in Print: 2013-02-01


Citation Information: BioMolecular Concepts, Volume 4, Issue 1, Pages 43–52, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc-2012-0041.

Export Citation

©2013 by Walter de Gruyter Berlin Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Junquan Weng, Wei Peng, Shuangxi Zhu, and Songling Chen
Implant Dentistry, 2017, Volume 26, Number 2, Page 178

Comments (0)

Please log in or register to comment.
Log in