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Biomolecular Concepts

Editor-in-Chief: Jollès, Pierre / Mansuy, Isabelle

Editorial Board Member: Avila, Jesus / Bonetto, Valentina / Cera, Enrico / Jorgensen, Erik / Jörnvall, Hans / Lagasse, Eric / Norman, Robert / Pinna, Lorenzo / Raghavan, K. Vijay / Venetianer, Pal / Wahli, Walter

6 Issues per year


CiteScore 2016: 2.39

SCImago Journal Rank (SJR) 2016: 0.753
Source Normalized Impact per Paper (SNIP) 2016: 0.567

Online
ISSN
1868-503X
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Elastin biology and tissue engineering with adult cells

Cassandra B. Saitow
  • Corresponding author
  • Tufts University, Department of Biomedical Engineering, Medford, MA, 02155, USA
  • Email:
/ Steven G. Wise
  • Heart Research Institute, Sydney, New South Wales, Australia
  • Molecular Biosciences, University of Sydney, Sydney, New South Wales, Australia
/ Anthony S. Weiss
  • Molecular Biosciences, University of Sydney, Sydney, New South Wales, Australia
/ John J. Castellot Jr
  • Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, 02111, USA
/ David L. Kaplan
  • Tufts University, Department of Biomedical Engineering, Medford, MA, 02155, USA
Published Online: 2013-01-25 | DOI: https://doi.org/10.1515/bmc-2012-0040

Abstract

The inability of adult cells to produce well-organized, robust elastic fibers has long been a barrier to the successful engineering of certain tissues. In this review, we focus primarily on elastin with respect to tissue-engineered vascular substitutes. To understand elastin regulation during normal development, we describe the role of various elastic fiber accessory proteins. Biochemical pathways regulating expression of the elastin gene are addressed, with particular focus on tissue-engineering research using adult-derived cells.

Keywords: elastin; heparin; smooth muscle cell; vascular tissue engineering

About the article

Corresponding author: Cassandra B. Saitow, Tufts University, Department of Biomedical Engineering, Medford, MA, 02155, USA


Received: 2012-09-27

Accepted: 2012-11-30

Published Online: 2013-01-25

Published in Print: 2013-04-01


Citation Information: BioMolecular Concepts, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc-2012-0040.

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©2013 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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