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Biomolecular Concepts

Editor-in-Chief: Di Cera, Enrico

Covered by Web of Science (BIOSIS Previews)

PubMed Indexed

CiteScore 2018: 3.35

SCImago Journal Rank (SJR) 2018: 1.475
Source Normalized Impact per Paper (SNIP) 2018: 0.825

ICV 2017: 131.30

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Volume 4, Issue 2


Elastin biology and tissue engineering with adult cells

Cassandra B. Saitow / Steven G. Wise
  • Heart Research Institute, Sydney, New South Wales, Australia
  • Molecular Biosciences, University of Sydney, Sydney, New South Wales, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Anthony S. Weiss / John J. Castellot Jr
  • Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, 02111, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ David L. Kaplan
Published Online: 2013-01-25 | DOI: https://doi.org/10.1515/bmc-2012-0040


The inability of adult cells to produce well-organized, robust elastic fibers has long been a barrier to the successful engineering of certain tissues. In this review, we focus primarily on elastin with respect to tissue-engineered vascular substitutes. To understand elastin regulation during normal development, we describe the role of various elastic fiber accessory proteins. Biochemical pathways regulating expression of the elastin gene are addressed, with particular focus on tissue-engineering research using adult-derived cells.

Keywords: elastin; heparin; smooth muscle cell; vascular tissue engineering

About the article

Corresponding author: Cassandra B. Saitow, Tufts University, Department of Biomedical Engineering, Medford, MA, 02155, USA

Received: 2012-09-27

Accepted: 2012-11-30

Published Online: 2013-01-25

Published in Print: 2013-04-01

Citation Information: BioMolecular Concepts, Volume 4, Issue 2, Pages 173–185, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: https://doi.org/10.1515/bmc-2012-0040.

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©2013 by Walter de Gruyter Berlin Boston.Get Permission

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