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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

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1862-278X
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Volume 50, Issue 12

Issues

Volume 57 (2012)

Heart tissue viability monitoring in vivo by using combined fluorescence, thermography and electrical activity measurements / In vivo Monitoring der Vitalität von Herzgewebe durch die kombinierte Messung mittels Fluoreszenz, Thermographie und elektrischer Aktivität.

A Kriščiukaitis
  • Corresponding author
  • Institute for Biomedical Research of Kaunas University of Medicine, Eiveniu str.4, LT-50009, Kaunas Lithuania.
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/ O Minet
  • Institute for Medical Physics and Laser Medicine of Charité Universitaetsmedizin Berlin, Campus Benjamin Franklin, Fabeckstr. 60-62, D-14195 Berlin, Germany.
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/ M Tamosiunas
  • Institute for Biomedical Research of Kaunas University of Medicine, Eiveniu str.4, LT-50009, Kaunas Lithuania.
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/ U Zabarylo
  • Institute for Medical Physics and Laser Medicine of Charité Universitaetsmedizin Berlin, Campus Benjamin Franklin, Fabeckstr. 60-62, D-14195 Berlin, Germany.
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/ A Bytautas
  • Institute for Biomedical Research of Kaunas University of Medicine, Eiveniu str.4, LT-50009, Kaunas Lithuania.
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/ R Baniene
  • Institute for Biomedical Research of Kaunas University of Medicine, Eiveniu str.4, LT-50009, Kaunas Lithuania.
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/ V Mildažiene
  • Institute for Biomedical Research of Kaunas University of Medicine, Eiveniu str.4, LT-50009, Kaunas Lithuania.
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/ R Lekas
  • Institute for Biomedical Research of Kaunas University of Medicine, Eiveniu str.4, LT-50009, Kaunas Lithuania.
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/ P Jakuska
  • Institute for Biomedical Research of Kaunas University of Medicine, Eiveniu str.4, LT-50009, Kaunas Lithuania.
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/ K Lukosevicius
  • Institute for Biomedical Research of Kaunas University of Medicine, Eiveniu str.4, LT-50009, Kaunas Lithuania.
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/ R Benetis
  • Institute of Cardiology of Kaunas University of Medicine, Sukileliu 17, LT-50009, Kaunas Lithuania.
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/ J Beuthan
  • Institute for Medical Physics and Laser Medicine of Charité Universitaetsmedizin Berlin, Campus Benjamin Franklin, Fabeckstr. 60-62, D-14195 Berlin, Germany.
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Published Online: 2008-03-17 | DOI: https://doi.org/10.1515/BMT.2005.059

Abstract

A prototype system for in vivo monitoring of the heart tissue viability by using combined measurements of fluorescence, thermography and electrical activity has been elaborated for cardiac surgery. The fluorescence imaging of nicotinamide adenine dinucleotide NAD(P)H in the blue light range (λ=467 nm) by using UV light (λ=347 nm) excitation was used to detect metabolic disturbances. The method of the principal component analysis was used for the processing of the fluorescence image sequences. Far infrared (λ=7.5 – 13 μm) imaging was used to evaluate temperature dynamics of the tissue surface during circulation disturbances. Evaluation of the epicardial electrogram shape by using continuous wavelet transform was used to detect and evaluate ischemia-caused disturbances of the electrical activity of the tissue. The combination of temperature, fluorescence and electrical activity estimates obtained from synchronically registered parameters during the experiments on model systems and experimental animals yielded qualitatively new results for the evaluation of cardiac tissue viability and enabled to achieve a versatile evaluation of the heart tissue viability.

 

Eine experimenteller Aufbau für das Monitoring der Herzvitalität in vivo wird vorgestellt. Die Kombination von Fuoreszenzbildgebung, Thermographie und EKG wurde für die Herzchirurgie entworfen. Änderungen des Stoffwechsels können durch ein 2D mapping der Fluoreszenz von Nicotinamide Adenine Dinucleotide NAD(P)H festgestellt werden. Die Anregung erfolgt bei 347 nm; die Fluoreszenz wird bei 467 nm detektiert. Die Bildsequenzen wurden mit einer Hauptkomponentenanalyse analysiert. Die Temperaturdynamik der Herzoberfläche während der Ischämie wird durch IR-Strahlung (λ=7.5 – 13 μm) abgebildet. Zusätzlich konnten die Störungen der elektrischen Aktivität durch ein EKG nach einer Wavelet-Transformation bewertet werden. Durch die Kombination der drei verschiedenen Methoden können synchrone Parameter an Modellsystemen und Versuchstieren gewonnen werden. Diese qualitativ neuen Ergebnisse dienen einer umfassenden Beurteilung der Vitalität von Herzgewebe.

Key words: Viability; heart; fluorescence; NAD(P)H; thermography; principal component analysis

Schlüsselwörter : Vitalität; Herz; Fluoreszenz; NAD(P)H; Thermographie; Hauptkomponentenanalyse

About the article

*Korrespondenzanschrift: Dr. Algimantas Kriščiukaitis, Institute for Biomedical Research of Kaunas, University of Medicine, Eiveniu str.4, LT-50009, Kaunas, Lithuania, Tel.: +37(27)73 11 72, Fax: +37(27)79 64 98


Published Online: 2008-03-17

Published in Print: 2005-12-01


Citation Information: Biomedizinische Technik/Biomedical Engineering, Volume 50, Issue 12, Pages 419–425, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/BMT.2005.059.

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