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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

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IMPACT FACTOR 2017: 1.096
5-year IMPACT FACTOR: 1.492

CiteScore 2017: 0.48

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1862-278X
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Volume 51, Issue 4

Issues

Volume 57 (2012)

Increase in regularity of fetal heart rate variability with age

Peter Van Leeuwen
  • Department of Biomagnetism, Grönemeyer Institute for Microtherapy, University Witten/Herdecke, Bochum, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dirk Cysarz
  • Chair of Medical Theory and Complementary Medicine, University Witten/Herdecke, Herdecke, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Silke Lange
  • Department of Biomagnetism, Grönemeyer Institute for Microtherapy, University Witten/Herdecke, Bochum, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dietrich Grönemeyer
  • Chair of Radiology and Microtherapy, Grönemeyer Institute for Microtherapy, University Witten/Herdecke, Bochum, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2006-10-25 | DOI: https://doi.org/10.1515/BMT.2006.047

Abstract

It is generally assumed that fetal heart rate variability increases with gestation, reflecting prenatal development of the autonomic nervous system. We examined standard measures quantifying fetal heart rate variability, as well as a complexity measure, approximate entropy, in 66 fetal magnetocardiograms recorded from 22 healthy pregnant women between the 16th and 42nd week of gestation. In particular, regularity in the fetal RR interval time series was assessed on the basis of symbolic dynamics. The results showed that, beside an overall increase in fetal heart rate variability and complexity during pregnancy, there was also an increase in specific sets of binary patterns with low approximate entropy, i.e., a high degree of regularity. These sets were characterized by short epochs of heart rate acceleration and deceleration, and comparison with surrogate data confirmed that their random occurrence is rare. The results most likely reflect the influence of increasingly differentiated fetal behavioral states and transitions between them in association with fetal development.

Keywords: approximate entropy; prenatal development; symbolic dynamics

About the article

Corresponding author: Peter Van Leeuwen, Department of Biomagnetism, Grönemeyer Institute for Microtherapy, University Witten/Herdecke, Universitätsstr. 142, 44799 Bochum, Germany Phone: +49-234-9780-140 Fax: +49-234-9780-599


Published Online: 2006-10-25

Published in Print: 2006-10-01


Citation Information: Biomedizinische Technik, Volume 51, Issue 4, Pages 244–247, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/BMT.2006.047.

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