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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

6 Issues per year


IMPACT FACTOR 2016: 0.915
5-year IMPACT FACTOR: 1.263

Online
ISSN
1862-278X
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Volume 53, Issue 3 (Jun 2008)

Issues

Volume 57 (2012)

Femoral stiffness and strength critically depend on loading angle: a parametric study in a mouse-inbred strain

Romain Voide / G. Harry van Lenthe / Ralph Müller
Published Online: 2008-05-22 | DOI: https://doi.org/10.1515/BMT.2008.019

Abstract

Biomechanical tests of human femora have shown that small variations of the loading direction result in significant changes in measured bone mechanical properties. However, the heterogeneity in geometrical and bone tissue properties does not make human bones well suited to reproducibly assess the effects of loading direction on stiffness and strength. To precisely quantify the influence of loading direction on stiffness and strength of femora loaded at the femoral head, we tested femora from C57BL/6 inbred mice. We developed an image-based alignment protocol and investigated the loading direction influence on proximal femur stiffness and strength. An aluminum femoral phantom and C57BL/6 femora were tested under compression with different loading directions. Both tests, with the aluminum phantom and the murine bones, showed and quantified the linear dependence of stiffness on loading direction: a 5° change in loading direction resulted in almost 30% change in stiffness. Murine bone testing also revealed and quantified the variation in strength due to loading direction: 5° change in loading direction resulted in 8.5% change in strength. In conclusion, this study quantified, for the first time, the influence of misalignment on bone stiffness and strength for femoral head loading. We showed the extreme sensitivity of this site regarding loading direction.

Keywords: aluminum phantom; biomechanical testing; loading direction; mouse strain; proximal femur

About the article

Corresponding author: Ralph Müller, Institute for Biomechanics, ETH Zürich, HCI E357.2, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland Phone: +41-44-632-4592 Fax: +41-44-632-1214


Received: 2007-06-14

Accepted: 2008-02-20

Published Online: 2008-05-22

Published Online: 2008-05-22

Published in Print: 2008-06-01


Citation Information: Biomedizinische Technik/Biomedical Engineering, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/BMT.2008.019.

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Citing Articles

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[1]
Maria-Grazia Ascenzi, Andre Lutz, Xia Du, Laureen Klimecky, Neal Kawas, Talia Hourany, Joelle Jahng, Jesse Chin, Yin Tintut, Udo Nackenhors, and Joyce Keyak
Journal of Biomechanics, 2014, Volume 47, Number 10, Page 2436
[2]
David W. Wagner, Stephanie Chan, Alesha B. Castillo, and Gary S. Beaupre
Journal of Biomechanics, 2013, Volume 46, Number 13, Page 2271
[3]
Roberto Carretta, Benoit Luisier, Daniel Bernoulli, Edgar Stüssi, Ralph Müller, and Silvio Lorenzetti
Journal of the Mechanical Behavior of Biomedical Materials, 2013, Volume 20, Page 6
[4]
D. Ruffoni, T. Kohler, R. Voide, A.J. Wirth, L.R. Donahue, R. Müller, and G.H. van Lenthe
Bone, 2013, Volume 55, Number 1, Page 216
[5]
Antonia Torcasio, Xiaolei Zhang, Joke Duyck, and G. Harry van Lenthe
Biomechanics and Modeling in Mechanobiology, 2012, Volume 11, Number 3-4, Page 403
[6]
R. Voide, P. Schneider, M. Stauber, P. Wyss, M. Stampanoni, U. Sennhauser, G.H. van Lenthe, and R. Müller
Bone, 2009, Volume 45, Number 2, Page 164
[7]
Kevin Mader, Federica Marone, Christoph Hintermüller, Gordan Mikuljan, Andreas Isenegger, and Marco Stampanoni
Journal of Synchrotron Radiation, 2011, Volume 18, Number 2, Page 117
[8]
L Cristofolini, M Juszczyk, F Taddei, and M Viceconti
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2009, Volume 223, Number 3, Page 273

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