Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

IMPACT FACTOR 2017: 1.096
5-year IMPACT FACTOR: 1.492

CiteScore 2017: 0.48

SCImago Journal Rank (SJR) 2017: 0.202
Source Normalized Impact per Paper (SNIP) 2017: 0.356

See all formats and pricing
More options …
Volume 53, Issue 3


Volume 57 (2012)

Femoral stiffness and strength critically depend on loading angle: a parametric study in a mouse-inbred strain

Romain Voide / G. Harry van Lenthe / Ralph Müller
Published Online: 2008-05-22 | DOI: https://doi.org/10.1515/BMT.2008.019


Biomechanical tests of human femora have shown that small variations of the loading direction result in significant changes in measured bone mechanical properties. However, the heterogeneity in geometrical and bone tissue properties does not make human bones well suited to reproducibly assess the effects of loading direction on stiffness and strength. To precisely quantify the influence of loading direction on stiffness and strength of femora loaded at the femoral head, we tested femora from C57BL/6 inbred mice. We developed an image-based alignment protocol and investigated the loading direction influence on proximal femur stiffness and strength. An aluminum femoral phantom and C57BL/6 femora were tested under compression with different loading directions. Both tests, with the aluminum phantom and the murine bones, showed and quantified the linear dependence of stiffness on loading direction: a 5° change in loading direction resulted in almost 30% change in stiffness. Murine bone testing also revealed and quantified the variation in strength due to loading direction: 5° change in loading direction resulted in 8.5% change in strength. In conclusion, this study quantified, for the first time, the influence of misalignment on bone stiffness and strength for femoral head loading. We showed the extreme sensitivity of this site regarding loading direction.

Keywords: aluminum phantom; biomechanical testing; loading direction; mouse strain; proximal femur

About the article

Corresponding author: Ralph Müller, Institute for Biomechanics, ETH Zürich, HCI E357.2, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland Phone: +41-44-632-4592 Fax: +41-44-632-1214

Received: 2007-06-14

Accepted: 2008-02-20

Published Online: 2008-05-22

Published Online: 2008-05-22

Published in Print: 2008-06-01

Citation Information: Biomedizinische Technik/Biomedical Engineering, Volume 53, Issue 3, Pages 122–129, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/BMT.2008.019.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Alina Levchuk, Philipp Schneider, Matias Meier, Peter Vogel, Finn Donaldson, and Ralph Müller
Frontiers in Materials, 2018, Volume 5
Maria-Grazia Ascenzi, Andre Lutz, Xia Du, Laureen Klimecky, Neal Kawas, Talia Hourany, Joelle Jahng, Jesse Chin, Yin Tintut, Udo Nackenhors, and Joyce Keyak
Journal of Biomechanics, 2014, Volume 47, Number 10, Page 2436
David W. Wagner, Stephanie Chan, Alesha B. Castillo, and Gary S. Beaupre
Journal of Biomechanics, 2013, Volume 46, Number 13, Page 2271
Roberto Carretta, Benoit Luisier, Daniel Bernoulli, Edgar Stüssi, Ralph Müller, and Silvio Lorenzetti
Journal of the Mechanical Behavior of Biomedical Materials, 2013, Volume 20, Page 6
D. Ruffoni, T. Kohler, R. Voide, A.J. Wirth, L.R. Donahue, R. Müller, and G.H. van Lenthe
Bone, 2013, Volume 55, Number 1, Page 216
Antonia Torcasio, Xiaolei Zhang, Joke Duyck, and G. Harry van Lenthe
Biomechanics and Modeling in Mechanobiology, 2012, Volume 11, Number 3-4, Page 403
R. Voide, P. Schneider, M. Stauber, P. Wyss, M. Stampanoni, U. Sennhauser, G.H. van Lenthe, and R. Müller
Bone, 2009, Volume 45, Number 2, Page 164
Kevin Mader, Federica Marone, Christoph Hintermüller, Gordan Mikuljan, Andreas Isenegger, and Marco Stampanoni
Journal of Synchrotron Radiation, 2011, Volume 18, Number 2, Page 117
L Cristofolini, M Juszczyk, F Taddei, and M Viceconti
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2009, Volume 223, Number 3, Page 273

Comments (0)

Please log in or register to comment.
Log in