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Biomedical Engineering / Biomedizinische Technik

Editor-in-Chief: Dössel, Olaf

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O-phospho-l-serine: a modulator of bone healing in calcium-phosphate cements

Ronald Mai1 / Romy Lux2 / Peter Proff3 / Günter Lauer4 / Winnie Pradel5 / Henry Leonhardt6 / Antje Reinstorf7 / Michael Gelinsky8 / Roland Jung9 / Uwe Eckelt10 / Tomasz Gedrange11 / Bernd Stadlinger12

1Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

2Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

3Department of Orthodontics, Regensburg University, Regensburg, Germany

4Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

5Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

6Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

7Max Bergmann Centre of Biomaterials, Technical University Dresden, Dresden, Germany

8Max Bergmann Centre of Biomaterials, Technical University Dresden, Dresden, Germany

9Experimental Centre, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

10Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

11Department of Orthodontics, Preventive and Paediatric Dentistry, Centre of Dentistry and Oral Health, Ernst Moritz Arndt University, Greifswald, Germany

12Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

Corresponding author: Dr. Ronald Mai, Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstr. 74, 01307 Dresden, Germany Phone: +49-351-458-5205 Fax: +49-351-458-3382

Citation Information: Biomedizinische Technik/Biomedical Engineering. Volume 53, Issue 5, Pages 229–233, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/BMT.2008.040, September 2008

Publication History

Received:
2007-06-01
Accepted:
2008-07-16
Published Online:
2008-09-22

Abstract

Bone substitution materials are seen as an alternative to autogenous bone transplants in the reconstruction of human bone structures. The aim of the present animal study was to evaluate the clinical handling and the conditions of bone healing after the application of a phosphoserine and collagen-I-modified calcium-phosphate cement (Biozement D). The application of phosphoserine is supposed to influence the texture of the extracellular matrix. Standardised bone defects were created in the lower jaw of 10 adult minipigs. These defects were reconstructed with a pasty calcium-phosphate cement mixture. After a healing time of 4 months, the animals were sacrificed. The mandibles of all animals were resected and non-decalcified histological sections of the areas of interest were prepared. The experiment was evaluated by means of qualitative histology and histomorphometry. The hydroxyapatite cement entirely hardened intraoperatively. Modelling and handling of the cement was facile and the margin fit to the host bone was excellent. Histology showed that resorption started in the periphery and proceeded exceptionally fast. The bony substitution, especially in phosphoserine-endowed cements, was very promising. After a healing period of 4 months, phosphoserine cements showed a bone regeneration of nearly two-thirds of the defect sizes. In the applied animal experiment, the newly developed hydroxyapatite collagen-I cement is well suited for bone substitution due to its easy handling, its excellent integration and good resorption characteristics. The addition of phosphoserine is very promising in terms of influencing resorption features and bone regeneration.

Keywords: bone defects; bone substitute materials; calcium-phosphate collagen cement; jaw; phosphoserine

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