Jump to ContentJump to Main Navigation
Show Summary Details

Biomedical Engineering / Biomedizinische Technik

Editor-in-Chief: Dössel, Olaf

Editorial Board Member: Augat, Peter / Haueisen, Jens / Jockenhoevel, Stefan / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Schmitz, Georg / Stieglitz, Thomas / Witte, Herbert / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen / Wintermantel, Erich /

6 Issues per year

IMPACT FACTOR increased in 2015: 1.650

See all formats and pricing


Select Volume and Issue


Volume 57 (2012)

30,00 € / $42.00 / £23.00

Get Access to Full Text

Post-processing technique for improved assessment of hard tissues in the submicrometer domain using local synchrotron radiation-based computed tomography / Nachbearbeitungstechnik für eine verbesserte Erfassung harten Gewebes im Submikrometerbereich mittels lokaler synchrotronstrahlungsbasierter Computertomographie

Philipp Schneider
  • 1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
/ Romain Voide
  • 2Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
/ Marco Stampanoni
  • 3Swiss Light Source (SLS), Paul Scherrer Institut (PSI), Villigen, Switzerland
/ Ralph Müller
  • 4Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
Published Online: 2009-01-30 | DOI: https://doi.org/10.1515/BMT.2009.007


During the last two decades micro-computed tomography has become the method of choice for the non-destructive assessment and quantitative morphometry of hard tissues in three dimensions. With the advent of third-generation synchrotron radiation sources, micro-computed tomography in the micrometer range has become feasible and has been employed to analyze local bone tissue properties. However, owing to limitations regarding the tradeoff between object size and spatial resolution, non-destructive conventional global computed tomography of hard tissues, such as bone, remains unachievable in the submicrometer domain so far. Here, we report on a post-processing technique for the assessment of hard tissues using local synchrotron radiation-based computed tomography, which overcomes this experimental limitation.


Hinsichtlich einer zerstörungsfreien Erfassung und quantitativen Morphometrie harten Gewebes in drei Dimensionen hat sich die Mikro-Computertomographie im Verlaufe der letzten zwei Jahrzehnte zur Methode der Wahl entwickelt. Mit dem Aufkommen von Synchrotronstrahlungsquellen der dritten Generation wurde Mikro-Computertomographie im Mikrometerbereich möglich und angewandt, um lokale Knocheneigenschaften zu untersuchen. Jedoch bleibt – infolge von Beschränkungen hinsichtlich des Kompromisses zwischen Objektgröße und Ortsauflösung – zerstörungsfreie herkömmliche globale Computertomographie für hartes Gewebe wie Knochen im Submikrometerbereich bis heute unerreichbar. An dieser Stelle berichten wir über eine Nachbearbeitungstechnik für die Erfassung harten Gewebes im Submikrometerbereich mittels synchrotronstrahlungsbasierter lokaler Computertomographie, die diese experimentelle Beschränkung überwindet.

Keywords: bone ultrastructure; canal network; cortical bone; cupping; morphometry; mouse; osteocyte lacunae; Cupping; kannuläres Netzwerk; Knochen-Ultrastruktur; kortikaler Knochen; Maus; Morphometrie; Osteozyt-Lakunen

Corresponding author: Prof. Dr. Ralph Müller, Institute for Biomechanics, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland Phone: +41-44-632-4592 Fax: +41-44-632-1214

Received: 2008-02-04

Accepted: 2008-10-10

Published Online: 2009-01-30

Published in Print: 2009-02-01

Citation Information: Biomedizinische Technik/Biomedical Engineering. Volume 54, Issue 1, Pages 48–54, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/BMT.2009.007, January 2009

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Finn Donaldson, Davide Ruffoni, Philipp Schneider, Alina Levchuk, Alexander Zwahlen, Pankaj Pankaj, and Ralph Müller
Biomechanics and Modeling in Mechanobiology, 2014, Volume 13, Number 6, Page 1227
Xiaoming Li, Lu Wang, Yubo Fan, Qingling Feng, Fu-Zhai Cui, and Fumio Watari
Journal of Biomedical Materials Research Part A, 2013, Volume 101A, Number 8, Page 2424
Philipp Schneider, Romain Voide, Marco Stampanoni, Leah Rae Donahue, and Ralph Müller
Bone, 2013, Volume 53, Number 1, Page 120
David Christen, Alina Levchuk, Stefan Schori, Philipp Schneider, Steven K. Boyd, and Ralph Müller
Journal of the Mechanical Behavior of Biomedical Materials, 2012, Volume 8, Page 184
Sabrina Lang, Marco Dominietto, Philippe Cattin, Alexandra Ulmann-Schuler, Timm Weitkamp, and Bert Müller
Journal of Synchrotron Radiation, 2012, Volume 19, Number 1, Page 114
R. Voide, P. Schneider, M. Stauber, G.H. van Lenthe, M. Stampanoni, and R. Müller
Bone, 2011, Volume 49, Number 6, Page 1186
A. Butscher, M. Bohner, S. Hofmann, L. Gauckler, and R. Müller
Acta Biomaterialia, 2011, Volume 7, Number 3, Page 907

Comments (0)

Please log in or register to comment.