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Biomedical Engineering / Biomedizinische Technik

Editor-in-Chief: Dössel, Olaf

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Volume 56, Issue 4 (Aug 2011)


Volume 57 (2012)

Preserved autonomic regulation in patients undergoing transcatheter aortic valve implantation (TAVI) – a prospective, comparative study

Beatrice Retzlaff
  • German Heart Center Munich, Munich, Germany
  • These authors contributed equally to the study.
/ Niels Wessel
  • Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germany
  • These authors contributed equally to the study.
  • Email:
/ Maik Riedl
  • Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germany
/ Andrej Gapelyuk
  • Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germany
/ Hagen Malberg
  • Institute of Biomedical Engineering, Dresden University of Technology, Dresden, Germany
/ Nina Bauernschmitt
  • German Heart Center Munich, Munich, Germany
/ Jürgen Kurths
  • Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germany
  • Transdisciplinary Concepts and Methods, Potsdam Institute for Climate Impact Research, Potsdam, Germany
/ Georg Bretthauer
  • Institute for Applied Computer Science, Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
/ Robert Bauernschmitt
  • Isar Heart-Center, Isarkliniken, Munich, Germany
Published Online: 2011-08-09 | DOI: https://doi.org/10.1515/bmt.2011.017


Heart rate and blood pressure variability as well as baroreflex sensitivity (BRS) lead to additional insights on the patients’ prognosis after cardiovascular events. The following study was performed to assess the differences in the postoperative recovery of the autonomic regulation after transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR). Fifty-eight consecutive patients were enrolled in a prospective study; 24 underwent TAVI and 34 SAVR. BRS was calculated according to the Dual Sequence Method, heart rate variability (HRV) was evaluated using standard linear as well as nonlinear parameters. HRV and BRS parameters were reduced after surgery in patients with SAVR only (meanNN: p<0.001, sdNN: p<0.05, Shannon: p<0.01, BRS: p<0.01), while these indexes were preserved in patients after TAVI. Simultaneously, an increased complexity of blood pressure (BP) in SAVR patients (fwShannon: p<0.001, fwRenyi4: p<0.001), but not in TAVI patients was recorded. In this study we were able to demonstrate for the first time that, in contrast to patients undergoing conventional open surgery, there are fewer alterations of the cardiovascular autonomic system in patients with TAVI.

Keywords: baroreflex sensitivity; blood pressure variability; heart rate variability; transcatheter valve procedures

About the article

Corresponding author: Niels Wessel, Department of Physics, Humboldt-Universität zu Berlin, Robert-Koch-Platz 4, D-10115, Berlin, Germany Phone: +49-30-2093-99181

Received: 2011-02-08

Accepted: 2011-07-18

Published Online: 2011-08-09

Published in Print: 2011-08-01

Citation Information: Biomedizinische Technik/Biomedical Engineering, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt.2011.017. Export Citation

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