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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /


IMPACT FACTOR 2018: 1.007
5-year IMPACT FACTOR: 1.390

CiteScore 2018: 1.24

SCImago Journal Rank (SJR) 2018: 0.282
Source Normalized Impact per Paper (SNIP) 2018: 0.831

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ISSN
1862-278X
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Volume 57, Issue 1

Issues

Volume 57 (2012)

Detection of surfactant proteins A, B, C, and D in human gingiva and saliva

Lars Bräuer
  • Department of Anatomy II, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
  • Contributed in equal parts to this work.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Martin Schicht
  • Department of Anatomy II, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
  • Contributed in equal parts to this work.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Christina Stengl
  • Department of Anatomy II, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Friedhelm Heinemann / Werner Götz
  • Labor für Oralbiologische Grundlagenforschung, Poliklinik für Kieferorthopädie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Bonn, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Michael Scholz
  • Department of Anatomy II, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Friedrich Paulsen
Published Online: 2012-01-10 | DOI: https://doi.org/10.1515/bmt-2011-0031

Abstract

Background: The oral cavity along with the teeth and the surrounding gingival epithelium is open to the oral environment and is thus exposed to multiple microbiological and pathogenic influences. To prevent permanent inflammatory processes such as gingivitis or parodontitis, an efficient defense system is necessary to sustain the physiological function of the oral cavity. Surfactant proteins (SPs), originally known from pulmonary tissue, are important players of the immune system and, beyond this, support the stability and rheology of gas or fluid interphases.

Methods: Here we evaluate the expression and presence of SPs (SP-A, SP-B, SP-C, and SP-D) in human gingiva and saliva. Messenger RNA expression of SP-A, SP-B, SP-C, and SP-D was analyzed by reverse transcriptase-polymerase chain reaction in healthy gingiva. The distribution of all four SPs was further determined with monoclonal antibodies using Western blot analyses and immunohistochemistry in healthy and pathologically changed tissues samples obtained during biopsies and in saliva of volunteers.

Results: Our results indicate that SP-A, SP-B, SP-C, and SP-D are peptides produced by healthy gingiva that reveal a changed expression pattern in cases of gingival disease.

Conclusion: Based on the known direct and indirect antimicrobial effects, SP-A and SP-D appear to be involved in immune defense within the oral cavity especially in direct proximity of teeth. Gingiva affected by bacterial inflammation (gingivitis) seems to increase expression of SPs. As a result, the rheology of saliva may be changed especially at the crest of the gingival epithelium to support the function of antimicrobial substances present in saliva. Furthermore, SPs could assist in pellicle formation on teeth, which needs to be determined in further experiments.

Keywords: gingival; inflammation; oral epithelium; surfactant proteins

About the article

Corresponding author: Friedrich Paulsen, Department of Anatomy II, Friedrich-Alexander-University Erlangen-Nürnberg, Universitätsstrasse 19, 91054 Erlangen, Germany


Received: 2011-10-13

Accepted: 2011-11-28

Published Online: 2012-01-10

Published in Print: 2012-02-01


Citation Information: Biomedizinische Technik/Biomedical Engineering, Volume 57, Issue 1, Pages 59–64, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2011-0031.

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[1]
Martin Schicht, Stephan Knipping, Roman Hirt, Stephanie Beileke, Saadettin Sel, Friedrich Paulsen, and Lars Bräuer
American Journal of Rhinology & Allergy, 2013, Volume 27, Number 1, Page 24
[2]
Andreas Posa, Friedrich Paulsen, Richard Dietz, Fabian Garreis, Ralph Sander, Martin Schicht, Saadettin Sel, Michael Scholz, Christian M. Hammer, and Lars Bräuer
Annals of Anatomy - Anatomischer Anzeiger, 2017
[3]
Stefan Schob, Martin Schicht, Saadettin Sel, Dankwart Stiller, Alexander Kekulé, Friedrich Paulsen, Erik Maronde, Lars Bräuer, and Jonathan A. Coles
PLoS ONE, 2013, Volume 8, Number 9, Page e74412
[4]
H. Schröder, R. Fischer, L. Sollfrank, F. Paulsen, L. Bräuer, and M. Schicht
Annals of Anatomy - Anatomischer Anzeiger, 2017, Volume 211, Page 149
[5]
M. Sheats, H. Schröder, F. Rausch, C. Bohr, F. Kißlinger, J. de Tristan, H. Iro, F. Garreis, F. Paulsen, M. Schicht, and L. Bräuer
Annals of Anatomy - Anatomischer Anzeiger, 2016, Volume 208, Page 135
[6]
H. Schröder, L. Sollfrank, F. Paulsen, L. Bräuer, and M. Schicht
Annals of Anatomy - Anatomischer Anzeiger, 2016, Volume 208, Page 129
[7]
Shanmuga Priyaa Madhukaran, Uday Kishore, Kaiser Jamil, Mahesh Choolani, and Jinhua Lu
Molecular Immunology, 2015, Volume 66, Number 2, Page 197
[8]
Edin Hamzić, Marie-Hélène Pinard-van der Laan, Bertrand Bed’Hom, and Helle Risdahl Juul-Madsen
Molecular Immunology, 2015, Volume 65, Number 2, Page 277
[9]
Patricia Silveyra and Joanna Floros
Gene, 2013, Volume 531, Number 2, Page 126

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