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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /


IMPACT FACTOR 2017: 1.096
5-year IMPACT FACTOR: 1.492

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1862-278X
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Volume 58, Issue 5

Issues

Volume 57 (2012)

Poly-4-hydroxybutyrate (P4HB): a new generation of resorbable medical devices for tissue repair and regeneration

Simon F. Williams / Said Rizk / David P. Martin
Published Online: 2013-06-12 | DOI: https://doi.org/10.1515/bmt-2013-0009

Abstract

Poly-4-hydroxybutyrate (P4HB) is a thermoplastic, linear polyester, produced by recombinant fermentation, that can be converted into a wide range of resorbable medical devices. P4HB fibers are exceptionally strong, and can be designed to provide prolonged strength retention in vivo. In 2007, the FDA cleared a monofilament suture made from P4HB for general soft tissue approximation and/or ligation. Subsequently, surgical mesh devices for hernia repair, tendon and ligament repair, and plastic and reconstructive surgery have been introduced for clinical use. This review describes the unique properties of P4HB, its clinical applications, and potential uses that are under development.

Keywords: absorbable; degradable; fiber; mesh; poly-4-hydroxybutyrate; resorbable

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About the article

Corresponding author: David P. Martin, Tepha, Inc., 99 Hayden Ave, Lexington, MA 02421, USA, Phone: +1 781 357 1702, E-mail:


Received: 2013-01-24

Accepted: 2013-05-13

Published Online: 2013-06-12

Published in Print: 2013-10-01


Citation Information: Biomedizinische Technik/Biomedical Engineering, Volume 58, Issue 5, Pages 439–452, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2013-0009.

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