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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

IMPACT FACTOR 2017: 1.096
5-year IMPACT FACTOR: 1.492

CiteScore 2017: 0.48

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Volume 59, Issue 3


Volume 57 (2012)

Bioartificial fabrication of regenerating blood vessel substitutes: requirements and current strategies

Mathias Wilhelmi
  • Department of Cardiothoracic-, Transplantation-, and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stefan Jockenhoevel
  • Department of Tissue Engineering and Textile Implants, Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Pauwelsstr. 20, 52072 Aachen, Germany
  • Institut für Textiltechnik, RWTH Aachen University, Otto-Blumenthal-Str. 1, 52074 Aachen, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Petra Mela
  • Corresponding author
  • Department of Tissue Engineering and Textile Implants, Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Pauwelsstr. 20, 52072 Aachen, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-03-01 | DOI: https://doi.org/10.1515/bmt-2013-0112


This work reviews the tremendous development in the field of vascular graft tissue engineering driven by a clear and increasing clinical need for functional vascular replacements able to grow and remodel. The different strategies to tissue engineer blood vessels are presented, from the classical approach of a living implant generated in vitro by conditioning a cell-seeded scaffold to remarkable paradigm shifts either i) toward a completely biology-driven strategy (scaffold-free approaches) or ii) the opposite tendency of cell-free scaffolds aiming at eliciting the host reaction for in situ tissue engineering. In the scaffold-based approaches emphasis is given to the material choice.

Keywords: bioartificial substitutes; biomaterials; blood vessels; scaffold; tissue engineering; vascular grafts


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About the article

Corresponding author: Petra Mela, Department of Tissue Engineering and Textile Implants, Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Pauwelsstr. 20, 52072 Aachen, Germany, Phone: +49 241 80 89886, Fax: +49 241 80 23402, E-mail: ;

Received: 2013-10-18

Accepted: 2014-02-03

Published Online: 2014-03-01

Published in Print: 2014-06-01

Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 59, Issue 3, Pages 185–195, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2013-0112.

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