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Merhof, Dorit

Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenarz, Thomas / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

IMPACT FACTOR 2018: 1.007
5-year IMPACT FACTOR: 1.390

CiteScore 2018: 1.24

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Volume 62, Issue 1


Volume 57 (2012)

Experimental study on the detection of rabbit intracranial hemorrhage using four coil structures based on magnetic induction phase shift

Qingguang Yan / Gui Jin / Mingxin Qin / Jun Zhao
  • Department of Radiology, Southwest Hospital, Third Military Medical University, Gaotanyanzheng Street 30, Chongqing 400038, Shapingba District, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jian Wang
  • Department of Radiology, Southwest Hospital, Third Military Medical University, Gaotanyanzheng Street 30, Chongqing 400038, Shapingba District, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jian Sun
Published Online: 2016-03-16 | DOI: https://doi.org/10.1515/bmt-2015-0129


Intracranial hemorrhage (ICH) is the bleeding induced by parenchyma vascular rupture. In this paper, four novel coils (a contralateral hemisphere cancellation coil, a coaxial coil, a double-end exciting coil, and a Helmholtz coil) were developed to detect the volume change of ICH with the magnetic induction phase shift (MIPS) technique. Both numerical studies on an ICH model and animal experiments on rabbits’ hemorrhage model were performed with four coils. Twenty rabbits were measured for each coil. The animal results were consistent with the simulation and the theoretical analysis for each coil. The MIPS first declined and then increased with increasing injection volume, indicating the existence of a turning point. The MRI images showed that the average CSF decreased in the heads of five rabbits after blood injection was approximately equal to the average injection volume corresponding to the turning point of all animals. Thus, we concluded that when the MIPS turning point occurs, the CSF is already exhausted and the compensatory stage has ended. The results show that the MIPS technique has the potential to detect ICH growth and MIPS changes with increasing blood in a regular way. The turning point is expected to provide an early warning for ICH growth.

Keywords: coils; intracranial hemorrhage; magnetic induction phase shift (MIPS); magnetic induction tomography


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About the article

Corresponding author: Mingxin Qin, College of Biomedical Engineering, Third Military Medical University, Gaotanyanzheng Street 30, Chongqing 400038, Shapingba District, China, E-mail:

aQingguang Yan and Gui Jin are co-first authors.

Received: 2015-07-03

Accepted: 2016-02-02

Published Online: 2016-03-16

Published in Print: 2017-02-01

Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 62, Issue 1, Pages 23–36, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2015-0129.

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