Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Merhof, Dorit

Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenarz, Thomas / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /


IMPACT FACTOR 2018: 1.007
5-year IMPACT FACTOR: 1.390

CiteScore 2018: 1.24

SCImago Journal Rank (SJR) 2018: 0.282
Source Normalized Impact per Paper (SNIP) 2018: 0.831

Online
ISSN
1862-278X
See all formats and pricing
More options …
Volume 62, Issue 1

Issues

Volume 57 (2012)

Experimental study on the detection of rabbit intracranial hemorrhage using four coil structures based on magnetic induction phase shift

Qingguang Yan / Gui Jin / Mingxin Qin / Jun Zhao
  • Department of Radiology, Southwest Hospital, Third Military Medical University, Gaotanyanzheng Street 30, Chongqing 400038, Shapingba District, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jian Wang
  • Department of Radiology, Southwest Hospital, Third Military Medical University, Gaotanyanzheng Street 30, Chongqing 400038, Shapingba District, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jian Sun
Published Online: 2016-03-16 | DOI: https://doi.org/10.1515/bmt-2015-0129

Abstract

Intracranial hemorrhage (ICH) is the bleeding induced by parenchyma vascular rupture. In this paper, four novel coils (a contralateral hemisphere cancellation coil, a coaxial coil, a double-end exciting coil, and a Helmholtz coil) were developed to detect the volume change of ICH with the magnetic induction phase shift (MIPS) technique. Both numerical studies on an ICH model and animal experiments on rabbits’ hemorrhage model were performed with four coils. Twenty rabbits were measured for each coil. The animal results were consistent with the simulation and the theoretical analysis for each coil. The MIPS first declined and then increased with increasing injection volume, indicating the existence of a turning point. The MRI images showed that the average CSF decreased in the heads of five rabbits after blood injection was approximately equal to the average injection volume corresponding to the turning point of all animals. Thus, we concluded that when the MIPS turning point occurs, the CSF is already exhausted and the compensatory stage has ended. The results show that the MIPS technique has the potential to detect ICH growth and MIPS changes with increasing blood in a regular way. The turning point is expected to provide an early warning for ICH growth.

Keywords: coils; intracranial hemorrhage; magnetic induction phase shift (MIPS); magnetic induction tomography

References

  • [1]

    Chen Y, Yan M, Chen D, et al. Imaging hemorrhagic stroke with magnetic induction tomography: realistic simulation and evaluation. Physiol Meas 2010; 31: 809–827.Google Scholar

  • [2]

    Gabriel C, Gabriel S, Corthout E. The dielectric properties of biological tissues: I. Literature survey. Phys Med Biol 1996; 41: 2231.Google Scholar

  • [3]

    González CA, Horowitz L, Rubinsky B. In vivo inductive phase shift measurements to detect intraperitoneal fluid. IEEE Trans Biomed Eng 2007; 54: 953–956.Google Scholar

  • [4]

    González CA, Lozano LM, Uscanga MC, et al. Theoretical and experimental estimations of volumetric inductive phase shift in breast cancer tissue. J Phys Conf Ser 2013; 434: 12004–12007(4).Google Scholar

  • [5]

    Gonzalez CA, Valencia JA, Mora A, et al. Volumetric electromagnetic phase-shift spectroscopy of brain edema and hematoma. PloS One 2013; 8: e63223.Google Scholar

  • [6]

    Gonzalez CA, Villanueva C, Vera C, et al. The detection of brain ischaemia in rats by inductive phase shift spectroscopy. Physiol Meas 2009; 30: 809–819.Google Scholar

  • [7]

    Griffiths H. Magnetic induction tomography. In: Holder DS, editor. Electrical impedance tomography: methods, history and applications. Bristol: Institute of Physics Publishing 2005: 213–238.Google Scholar

  • [8]

    Griffiths H, Stewart WR, Gough W. Magnetic induction tomography: a measuring system for biological tissues. Ann NY Acad Sci 1999; 873: 335–345.Google Scholar

  • [9]

    Helsinki F. Declaration of helsinki. Br Med J 1996; 313: 1448–1449.Google Scholar

  • [10]

    Jin G, Sun J, Qin MX, et al. A new method for detecting cerebral hemorrhage in rabbits by magnetic inductive phase shift. Biosens Bioelectron 2014; 52: 374–378.Google Scholar

  • [11]

    Leira R, Dávalos A, Silva Y, et al. Early neurologic deterioration in intracerebral hemorrhage predictors and associated factors. Neurology 2004; 63: 461–467.Google Scholar

  • [12]

    Liu CJ. Cerebrovascular surgery. Nanjing: Jiangsu Science and Technology Publishing Press 2000: 307–341.Google Scholar

  • [13]

    Riedel CH, Keppelen M, Nani S, Merges RD, Dossel O. Planar system for magnetic induction conductivity measurement using a sensor matrix. Physiol Meas 2004; 25: 403–411.Google Scholar

  • [14]

    Sawyer CH, Everett JW, Green JD. The rabbit diencephalon in stereotaxic coordinates. J Comp Neurol 1954; 101: 801–824.Google Scholar

  • [15]

    Scharfetter H, Lackner HK, Rosell J. Magnetic induction tomography: hardware for multi-frequency measurements in biological tissues. Physiol Meas 2001; 22: 131–146.Google Scholar

  • [16]

    Wang ZC. Neurosurgery. Wuhan: Hubei Science and Technology Publishing Press 1998: 20–60.Google Scholar

  • [17]

    Watson S, Morris A, Williams RJ, Griffiths H, Gough W. A primary field compensation scheme for planar array magnetic induction tomography. Physiol Meas 2004; 25: 271–279.Google Scholar

  • [18]

    Watson S, Williams RJ, Griffiths H, et al. Magnetic induction tomography: phase versus vector-voltmeter measurement techniques. Physiol Meas 2003; 24: 555–564.Google Scholar

  • [19]

    Zhu CH. Neuroanatomy. Beijing: People’s Medical Publishing Press 2002: 986–1032.Google Scholar

  • [20]

    Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16: 109–100.Google Scholar

About the article

Corresponding author: Mingxin Qin, College of Biomedical Engineering, Third Military Medical University, Gaotanyanzheng Street 30, Chongqing 400038, Shapingba District, China, E-mail:

aQingguang Yan and Gui Jin are co-first authors.


Received: 2015-07-03

Accepted: 2016-02-02

Published Online: 2016-03-16

Published in Print: 2017-02-01


Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 62, Issue 1, Pages 23–36, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2015-0129.

Export Citation

©2017 Walter de Gruyter GmbH, Berlin/Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Zelin Bai, Qingguang Yan, Gen Li, Wei Zhuang, Jingbo Chen, Jun Yang, Jia Xu, Lin Lu, Mingsheng Chen, Lin Xu, Mingxin Qin, and Gui Jin
Measurement Science and Technology, 2019, Volume 30, Number 11, Page 115701
[2]
Gen Li, Ke Ma, Jian Sun, Gui Jin, Mingxin Qin, and Hua Feng
Sensors, 2017, Volume 17, Number 3, Page 537

Comments (0)

Please log in or register to comment.
Log in