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Merhof, Dorit

Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenarz, Thomas / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

IMPACT FACTOR 2018: 1.007
5-year IMPACT FACTOR: 1.390

CiteScore 2018: 1.24

SCImago Journal Rank (SJR) 2018: 0.282
Source Normalized Impact per Paper (SNIP) 2018: 0.831

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Volume 62, Issue 1


Volume 57 (2012)

Hyaluronic acid-modified zirconium phosphate nanoparticles for potential lung cancer therapy

Ranwei Li
  • Department of Urinary Surgery, The Second Affiliated Hospital of Jilin University, Changchun, Jilin, 130041, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tiecheng Liu
  • Department of anesthesiology, The Second Affiliated Hospital of Jilin University, Changchun, Jilin, 130041, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ke Wang
  • Corresponding author
  • Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin University, Changchun, Jilin, 130041, China
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-04-23 | DOI: https://doi.org/10.1515/bmt-2015-0238


Novel tumor-targeting zirconium phosphate (ZP) nanoparticles modified with hyaluronic acid (HA) were developed (HA-ZP), with the aim of combining the drug-loading property of ZP and the tumor-targeting ability of HA to construct a tumor-targeting paclitaxel (PTX) delivery system for potential lung cancer therapy. The experimental results indicated that PTX loading into the HA-ZP nanoparticles was as high as 20.36%±4.37%, which is favorable for cancer therapy. PTX-loaded HA-ZP nanoparticles increased the accumulation of PTX in A549 lung cancer cells via HA-mediated endocytosis and exhibited superior anticancer activity in vitro. In vivo anticancer efficacy assay revealed that HA-ZP nanoparticles possessed preferable anticancer abilities, which exhibited minimized toxic side effects of PTX and strong tumor-suppression potential in clinical application.

Keywords: hyaluronic acid; lung cancer; paclitaxel; zirconium phosphate


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About the article

aRanwei Li and Tiecheng Liu: These authors contributed equally to this work.

Received: 2015-12-14

Accepted: 2016-03-09

Published Online: 2016-04-23

Published in Print: 2017-02-01

Funding Source: Natural Science Foundation of Jilin Province

Award identifier / Grant number: 20150101151JC

We greatly acknowledge the financial support from Provincial Training Program of Science and Technology for Innovative Talents of Jin (20130521002JH) and Natural Science Foundation of Jilin Province (20150101151JC).

Conflict of interest statement: The authors report no conflict of interests.

Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 62, Issue 1, Pages 67–73, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2015-0238.

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