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Merhof, Dorit

Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenarz, Thomas / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

IMPACT FACTOR 2018: 1.007
5-year IMPACT FACTOR: 1.390

CiteScore 2018: 1.24

SCImago Journal Rank (SJR) 2018: 0.282
Source Normalized Impact per Paper (SNIP) 2018: 0.831

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Volume 62, Issue 2


Volume 57 (2012)

Design of a right ventricular mock circulation loop as a test bench for right ventricular assist devices

Indra Mueller
  • Corresponding author
  • Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, Pauwelsstr.20, 52074 Aachen, Germany, Phone: +49 241 80-89168, Fax: +49 241 80-82144
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ So-Hyun Jansen-Park
  • Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, 52074 Aachen, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Michael Neidlin
  • Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, 52074 Aachen, Germany
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/ Ulrich Steinseifer
  • Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, 52074 Aachen, Germany
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/ Dirk Abel / Rüdiger Autschbach
  • Department of Cardiothoracic and Vascular Surgery, University Hospital RWTH Aachen, 52074 Aachen, Germany
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/ Rolf Rossaint / Thomas Schmitz-Rode
  • Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, 52074 Aachen, Germany
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/ Simon Johannes Sonntag
  • Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, 52074 Aachen, Germany
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-12-17 | DOI: https://doi.org/10.1515/bmt-2016-0104


Right heart failure (RHF), e.g. due to pulmonary hypertension (PH), is a serious health issue with growing occurrence and high mortality rate. Limited efficacy of medication in advanced stages of the disease constitutes the need for mechanical circulatory support of the right ventricle (RV). An essential contribution to the process of developing right ventricular assist devices (RVADs) is the in vitro test bench, which simulates the hemodynamic behavior of the native circulatory system. To model healthy and diseased arterial-pulmonary hemodynamics in adults (mild and severe PH and RHF), a right heart mock circulation loop (MCL) was developed. Incorporating an anatomically shaped silicone RV and a silicone atrium, it not only enables investigations of hemodynamic values but also suction events or the handling of minimal invasive RVADs in an anatomical test environment. Ventricular pressure-volume loops of all simulated conditions as well as pressure and volume waveforms were recorded and compared to literature data. In an exemplary test, an RVAD was connected to the apex to further test the feasibility of studying such devices with the developed MCL. In conclusion, the hemodynamic behavior of the native system was well reproduced by the developed MCL, which is a useful basis for future RVAD tests.

Keywords: anatomical mock ventricle; cannula; mechanical circulatory support; pulmonary hypertension; pulmonary mock circulation; right heart failure


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About the article

Received: 2016-05-02

Accepted: 2016-10-27

Published Online: 2016-12-17

Published in Print: 2017-04-01

Financial support: This study was funded by the German Research Foundation (SCHM 1307/12-1 and SCHM 1307/13-1).

Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 62, Issue 2, Pages 131–137, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2016-0104.

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