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Licensed Unlicensed Requires Authentication Published by De Gruyter December 17, 2016

Design of a right ventricular mock circulation loop as a test bench for right ventricular assist devices

  • Indra Mueller EMAIL logo , So-Hyun Jansen-Park , Michael Neidlin , Ulrich Steinseifer , Dirk Abel , Rüdiger Autschbach , Rolf Rossaint , Thomas Schmitz-Rode and Simon Johannes Sonntag

Abstract

Right heart failure (RHF), e.g. due to pulmonary hypertension (PH), is a serious health issue with growing occurrence and high mortality rate. Limited efficacy of medication in advanced stages of the disease constitutes the need for mechanical circulatory support of the right ventricle (RV). An essential contribution to the process of developing right ventricular assist devices (RVADs) is the in vitro test bench, which simulates the hemodynamic behavior of the native circulatory system. To model healthy and diseased arterial-pulmonary hemodynamics in adults (mild and severe PH and RHF), a right heart mock circulation loop (MCL) was developed. Incorporating an anatomically shaped silicone RV and a silicone atrium, it not only enables investigations of hemodynamic values but also suction events or the handling of minimal invasive RVADs in an anatomical test environment. Ventricular pressure-volume loops of all simulated conditions as well as pressure and volume waveforms were recorded and compared to literature data. In an exemplary test, an RVAD was connected to the apex to further test the feasibility of studying such devices with the developed MCL. In conclusion, the hemodynamic behavior of the native system was well reproduced by the developed MCL, which is a useful basis for future RVAD tests.

  1. Financial support: This study was funded by the German Research Foundation (SCHM 1307/12-1 and SCHM 1307/13-1).

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Received: 2016-5-2
Accepted: 2016-10-27
Published Online: 2016-12-17
Published in Print: 2017-4-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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