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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

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Volume 62, Issue 6 (Nov 2017)

Issues

Volume 57 (2012)

Response of a physiological controller for ventricular assist devices during acute patho-physiological events: an in vitro study

Anastasios Petrou
  • pd|z Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland
  • Other articles by this author:
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/ Panagiotis Pergantis
  • German Heart Institute Berlin, Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1, 13353 Berlin, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gregor Ochsner
  • pd|z Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland
  • Institute for Dynamic Systems and Control, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Raffael Amacher / Thomas Krabatsch
  • German Heart Institute Berlin, Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1, 13353 Berlin, Germany
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/ Volkmar Falk
  • German Heart Institute Berlin, Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1, 13353 Berlin, Germany
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/ Mirko Meboldt
  • pd|z Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland
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/ Marianne Schmid Daners
  • Corresponding author
  • pd|z Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, CLA G21.1 Tannenstr. 3, 8092 Zurich, Switzerland, Phone: + 41 44 632 2447
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Published Online: 2017-02-09 | DOI: https://doi.org/10.1515/bmt-2016-0155

Abstract

The current paper analyzes the performance of a physiological controller for turbodynamic ventricular assist devices (tVADs) during acute patho-physiological events. The numerical model of the human blood circulation implemented on our hybrid mock circulation was extended in order to simulate the Valsalva maneuver (VM) and premature ventricular contractions (PVCs). The performance of an end-diastolic volume (EDV)-based physiological controller for VADs, named preload responsive speed (PRS) controller was evaluated under VM and PVCs. A slow and a fast response of the PRS controller were implemented by using a 3 s moving window, and a beat-to-beat method, respectively, to extract the EDV index. The hemodynamics of a pathological circulation, assisted by a tVAD controlled by the PRS controller were analyzed and compared with a constant speed support case. The results show that the PRS controller prevented suction during the VM with both methods, while with constant speed, this was not the case. On the other hand, the pump flow reduction with the PRS controller led to low aortic pressure, while it remained physiological with the constant speed control. Pump backflow was increased when the moving window was used but it avoided sudden undesirable speed changes, which occurred during PVCs with the beat-to-beat method. In a possible clinical implementation of any physiological controller, the desired performance during frequent clinical acute scenarios should be considered.

Keywords: physiological control; premature ventricular contraction (PVC); suction; Valsalva maneuver (VM); ventricular assist device (VAD); volume measurement

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About the article

aThese authors contributed equally to the study.


Received: 2016-07-12

Accepted: 2017-01-05

Published Online: 2017-02-09

Published in Print: 2017-11-27


Funding: The authors gratefully acknowledge the financial support by the Stavros Niarchos Foundation. This work is part of the Zurich Heart project under the umbrella of “University Medicine Zurich”.

Conflict of interest: The authors declare no conflict of interest.


Citation Information: Biomedical Engineering / Biomedizinische Technik, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2016-0155.

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