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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

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Volume 63, Issue 5

Issues

Volume 57 (2012)

Diffuse near-infrared imaging of tissue with picosecond time resolution

Dirk Grosenick
  • Corresponding author
  • Physikalisch-Technische Bundesanstalt (PTB), Abbestraße 2–12, 10587 Berlin, Germany, Phone: +49 30 3481-7302, Fax: +49 30 3481-7505
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/ Heidrun Wabnitz / Rainer Macdonald
Published Online: 2018-03-01 | DOI: https://doi.org/10.1515/bmt-2017-0067

Abstract

Optical imaging of biological tissue in vivo at multiple wavelengths in the near-infrared (NIR) spectral range can be achieved with picosecond time resolution at high sensitivity by time-correlated single photon counting. Measuring and analyzing the distribution of times of flight of photons randomly propagated through the tissue has been applied for diffuse optical imaging and spectroscopy, e.g. of human breast tissue and of the brain. In this article, we review the main features and the potential of NIR multispectral imaging with picosecond time resolution and illustrate them by exemplar applications in these fields. In particular, we discuss the experimental methods developed at the Physikalisch-Technische Bundesanstalt (PTB) to record optical mammograms and to quantify the absorption and scattering properties from which hemoglobin concentration and oxygen saturation of healthy and diseased breast tissue have been derived by combining picosecond time-domain and spectral information. Furthermore, optical images of functional brain activation were obtained by a non-contact scanning device exploiting the null source-detector separation approach which takes advantage of the picosecond time resolution as well. The recorded time traces of changes in the oxy- and deoxyhemoglobin concentrations during a motor stimulation investigation show a localized response from the brain.

Keywords: diffuse optical imaging; fNIRS; near-infrared spectroscopy; optical mammography; time-resolved optical imaging

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About the article

Received: 2017-05-16

Accepted: 2017-12-04

Published Online: 2018-03-01

Published in Print: 2018-10-25


Author Statement

Research funding: Authors state no funding involved.

Conflict of interest: Authors state no conflict of interest.


Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 63, Issue 5, Pages 511–518, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2017-0067.

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