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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

IMPACT FACTOR 2017: 1.096
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Volume 63, Issue 5


Volume 57 (2012)

Hyperspectral imaging as a possible tool for visualization of changes in hemoglobin oxygenation in patients with deficient hemodynamics – proof of concept

Claudia Sicher / Rico Rutkowski
  • Department of Oral and Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, Greifswald, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stine Lutze / Sebastian von Podewils / Thomas Wild
  • Department of Dermatology, Venerology, Allergology and Immunology Center, Dessau Medical Center, Theodor Fontane Medical University Brandenburg, Dessau-Roßlau, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Markus Kretching
  • Department of Traumatology and Reconstructive Surgery, University Medicine Greifswald, Greifswald, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Georg Daeschlein
Published Online: 2018-09-13 | DOI: https://doi.org/10.1515/bmt-2017-0084


There is a lack of imaging tools for the evaluation of spatial alterations in microcirculation including blood oxygen saturation and hemoglobin distribution but recent innovative developments in hyperspectral technology may offer a solution. We examined different hemodynamic disorders in patients suffering from scleroderma, Dupuytren surgery, chronic foot ulcera and skin infections. Superficial and deeper blood oxygen saturation, hemoglobin distribution and water content were determined using hyperspectral imaging (HSI). In the patient with scleroderma, distinct cutaneous low perfused regions correlated with macroscopic skin aspects and seem to be potential therapy control marker. With HSI accurate clinical evaluation of a macroscopic conspicuous wound after Dupuytren surgery was possible and influenced further surveillance decisions. HSI clearly revealed the spatial geometry and also the clinically related perfusion parameters of abscess formation and chronic ulcer wounds. The hemodynamically relevant parameters like blood oxygen saturation (1 mm to approx. 6 mm subcutaneous), total hemoglobin distribution and tissue water content can be easily determined and visualized with HSI in near real time. Hence, this technique seems to be suitable for routine diagnostics of acute and chronic wounds as well as for the examination of systemic hemodynamic disturbances. Special indications may be transplant surveillance and monitoring of therapeutical interventions.

Keywords: hemodynamic alteration; microcirculation; oxygen saturation; wound healing; wound medicine


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About the article

Corresponding author: Claudia Sicher, MSc, Department of Dermatology, University Medicine Greifswald, Sauerbruchstraße, 17475 Greifswald, Germany, Phone: +49 3834 86 22980, Fax: +49 3834 86 6772

aRico Rutkowski and Stine Lutze: Authors with equal participation.

Received: 2017-05-31

Accepted: 2018-09-04

Published Online: 2018-09-13

Published in Print: 2018-10-25

Author Statement

Research funding: Authors state no funding involved.

Conflict of interest: Authors state no conflict of interest.

Informed consent: Informed consent has been obtained from all individuals.

Ethical approval: The research related to human use complied with all the relevant national regulations and institutional policies and was performed in accordance to the tenets of the Declaration of Helsinki and has been approved by the author’s institutional review board or equivalent committee.

Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 63, Issue 5, Pages 609–616, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2017-0084.

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