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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

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Volume 63, Issue 5


Volume 57 (2012)

Hyperspectral imaging: innovative diagnostics to visualize hemodynamic effects of cold plasma in wound therapy

Georg Daeschlein / Rico Rutkowski
  • Department of Oral and Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, Greifswald, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stine Lutze / Sebastian von Podewils / Claudia Sicher / Thomas Wild
  • Departments of Dermatology, Venerology, Allergology and Immunology Center, Dessau Medical Center, Theodor Fontane Medical University Brandenburg, Dessau-Roßlau, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Hans-Robert Metelmann
  • Department of Oral and Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, Greifswald, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Thomas von Woedkte / Michael Jünger
Published Online: 2018-05-04 | DOI: https://doi.org/10.1515/bmt-2017-0085


An important clinical potential of cold atmospheric plasma (CAP) lies in tumor and wound treatment, whereby the last-mentioned is well-referenced already. However, the underlying mechanisms of improved wound healing have not been sufficiently clarified yet, in particular the influence of CAP on microcirculation. Hyperspectral imaging (HSI) enables the visualization of microcirculation of large tissue areas, thus this technique seems to be a candidate to examine CAP effects on perfusion and oxygen saturation in wounds. During clinical wound management, one chronic wound caused by peripheral arterial occlusive disease and one acute wound after surgical removal of cervical lymph nodes were examined using HSI before and after CAP treatment. HSI was able to demonstrate CAP effects on microcirculation showing a relevant increase of superficial and deeper cutaneous oxygen saturation together with elevated hemoglobin concentration in treated and also surrounding wound area. For the first time, it was shown that CAP improves the superficial and deeper oxygenation and hemoglobin perfusion in and around the treated area of acute and chronic wounds. This effect may contribute to healing support by CAP in wounds. HSI seems suitable for evaluating and monitoring CAP effects in clinical settings.

Keywords: cold atmospheric plasma; hemoglobin; hyperspectral imaging; oxygen saturation; perfusion; wound healing


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About the article

Corresponding author: apl. Prof. Dr. med Georg Daeschlein, Department of Dermatology, University Medicine Greifswald, Sauerbruchstraße, Greifswald 17475, Germany, Phone: +493834 86 6770, Fax: +493834 86 6772

aGeorg Daeschlein and Rico Rutkowski: Equal participation.

Received: 2017-05-31

Accepted: 2018-03-28

Published Online: 2018-05-04

Published in Print: 2018-10-25

Author Statement

Research funding: Authors state no funding involved.

Conflict of interest: Authors state no conflict of interest.

Informed consent: Informed consent has been obtained from all individuals.

Ethical approval: The research related to human use complied with all the relevant national regulations and institutional policies, was performed in accordance with the tenets of the Helsinki Declaration, and has been approved by the local institutional review board.

Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 63, Issue 5, Pages 603–608, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2017-0085.

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