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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

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Volume 63, Issue 6


Volume 57 (2012)

Response time of indirectly accessed gas exchange depends on measurement method

Jakub RaflORCID iD: http://orcid.org/0000-0001-5102-9354 / Filip Kulhanek
  • Czech Technical University in Prague, Faculty of Biomedical Engineering, Department of Biomedical Technology, 272 01 Kladno, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Petr Kudrna
  • Czech Technical University in Prague, Faculty of Biomedical Engineering, Department of Biomedical Technology, 272 01 Kladno, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Vaclav Ort
  • Czech Technical University in Prague, Faculty of Biomedical Engineering, Department of Biomedical Technology, 272 01 Kladno, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Karel Roubik
  • Czech Technical University in Prague, Faculty of Biomedical Engineering, Department of Biomedical Technology, 272 01 Kladno, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-08-12 | DOI: https://doi.org/10.1515/bmt-2017-0070


Noninvasive techniques are routinely used for assessment of tissue effects of lung ventilation. However, comprehensive studies of the response time of the methods are scarce. The aim of this study was to compare the response time of noninvasive methods for monitoring of gas exchange to sudden changes in the composition of the inspired gas. A prospective experimental study with 16 healthy volunteers was conducted. A ventilation circuit was designed that enabled a fast change in the composition of the inspiratory gas mixture while allowing spontaneous breathing. The volunteers inhaled a hypoxic mixture, then a hypercapnic mixture, a hyperoxic mixture and finally a 0.3% CO mixture. The parameters with the fastest response to the sudden change of O2 in inhaled gas were peripheral capillary oxygen saturation (SpO2) and regional tissue oxygenation (rSO2). Transcutaneous oxygen partial pressure (tcpO2) had almost the same time of reaction, but its time of relaxation was 2–3 times longer. End-tidal carbon dioxide (EtCO2) response time to change of CO2 concentration in inhaled gas was less than half in comparison with transcutaneous carbon dioxide partial pressure (tcpCO2). All the examined parameters and devices reacted adequately to changes in gas concentration in the inspiratory gas mixture.

Keywords: near infrared spectroscopy; non-invasive respiratory monitoring; pulse oximetry; transcutaneous monitoring


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About the article

Received: 2016-12-18

Accepted: 2017-07-03

Published Online: 2017-08-12

Published in Print: 2018-11-27

Funding: The work was supported by grant SGS17/203/OHK4/3T/17 of the Czech Technical University in Prague and by project reg.no. CZ.2.16/3.1.00/21564 from OP Prague Competitiveness.

Conflict of interest statement: The authors state no conflict of interest.

Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 63, Issue 6, Pages 647–655, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2017-0070.

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